| Literature DB >> 22980779 |
Zong-Tsi Chen1, Heuy-Ling Chu, Charng-Cherng Chyau, Chin-Chen Chu, Pin-Der Duh.
Abstract
Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress were investigated. According to HPLC-DAD and HPLC-MS/MS analysis, hesperidin (HD), hesperetin (HT), nobiletin (NT), and tangeretin (TT) were present in water extracts of sweet orange peel (WESP). The cytotoxic effect in 0.2mM t-BHP-induced HepG2 cells was inhibited by WESP and their bioactive compounds. The protective effect of WESP and their bioactive compounds in 0.2mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation. Overall, WESP displayed a significant cytoprotective effect against oxidative stress, which may be most likely because of the phenolics-related bioactive compounds in WESP, leading to maintenance of the normal redox status of cells.Entities:
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Year: 2012 PMID： 22980779 DOI： 10.1016/j.foodchem.2012.07.041
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514