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Literature DB >> 229797

Rhinoviruses: kinetics of ultraviolet inactivation and effects of UV and heat on immunogenicity.

Abstract

The kinetics of ultraviolet inactivation for two human rhinoviruses and poliovirus were compared. No major differences in the rates of ultraviolet inactivation were detectable. All viral preparations inactivated by ultraviolet irradiation induced neutralizing antibody in guinea pigs. In contrast, when guinea pigs were immunized with a heat inactivated rhinovirus preparation, little or no neutralizing antibody was elicited. Immune electron microscopy of the heated rhinovirus preparations revealed the presence of particles resembling empty capsids. These results suggest that rhinoviruses and enteroviruses are affected in a similar manner when subjected to ultraviolet or heat inactivation.

Entities: Species

Mesh：

Substances：
Antibodies, Viral

Year: 1979 PMID： 229797 DOI： 10.1007/bf01315018

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

30 in total

1. Studies on the complement fixing antigens of poliomyelitis. I. Demonstration of type and group specific antigens in native and heated viral preparations.

Authors: K HUMMELER; V V HAMPARIAN
Journal: J Immunol Date: 1958-12 Impact factor: 5.422

2. Identification of poliovirus particles of different antigenicity by specific agglutination as seen in the electron microscope.

Authors: K HUMMELER; T F ANDERSON; R A BROWN
Journal: Virology Date: 1962-01 Impact factor: 3.616

9. PROPERTIES OF THE CAUSATIVE AGENT OF A CHICKEN TUMOR : II. THE INACTIVATION OF THE TUMOR-PRODUCING AGENT BY MONOCHROMATIC ULTRA-VIOLET LIGHT.

Authors: E Sturm; F L Gates; J B Murphy
Journal: J Exp Med Date: 1932-02-29 Impact factor: 14.307

10. Modification of the homotypic specificity of poliomyelitis complement-fixing antigens by heat.

Authors: N J SCHMIDT; E H LENNETTE
Journal: J Exp Med Date: 1956-07-01 Impact factor: 14.307

4 in total

1. Infection of a human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure.

Authors: M C Subauste; D B Jacoby; S M Richards; D Proud
Journal: J Clin Invest Date: 1995-07 Impact factor: 14.808

Rhinoviruses: kinetics of ultraviolet inactivation and effects of UV and heat on immunogenicity.

1. Studies on the complement fixing antigens of poliomyelitis. I. Demonstration of type and group specific antigens in native and heated viral preparations.

2. Identification of poliovirus particles of different antigenicity by specific agglutination as seen in the electron microscope.

3. The D to C change in poliovirus particles.

4. Studies on the degradation of poliovirus by heat.

5. Acid lability of rhinoviruses: loss of C and D antigenicity after treatment at pH 3.0.

6. Internal components released from rhinovirus and poliovirus by heat.

7. Immune responses to H particles of poliovirus.

8. Formation of fibrillar structures from poliovirus by alkaline disruption and other treatments.

9. PROPERTIES OF THE CAUSATIVE AGENT OF A CHICKEN TUMOR : II. THE INACTIVATION OF THE TUMOR-PRODUCING AGENT BY MONOCHROMATIC ULTRA-VIOLET LIGHT.

10. Modification of the homotypic specificity of poliomyelitis complement-fixing antigens by heat.

1. Infection of a human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure.

2. Analysis of antibody responses to predominant linear epitopes of Theiler's murine encephalomyelitis virus.

3. Developing a vaccine for human rhinoviruses.

Review 4. Diagnostic virology using electron microscopic techniques.