BACKGROUND: African catarrhine primates differ in bacterial disease susceptibility. METHODS: Human, chimpanzee, and baboon blood were stimulated with TLR-detected bacterial agonists and cytokine/chemokine induction assessed by real-time PCR. RESULTS: Humans and chimpanzees shared similar cytokine/chemokine responses, while baboon cytokine/chemokine induction differed. Generally, responses were agonist independent. CONCLUSIONS: These primates tend to generate species rather than agonist-specific responses to bacterial agonists.
BACKGROUND: African catarrhine primates differ in bacterial disease susceptibility. METHODS:Human, chimpanzee, and baboon blood were stimulated with TLR-detected bacterial agonists and cytokine/chemokine induction assessed by real-time PCR. RESULTS:Humans and chimpanzees shared similar cytokine/chemokine responses, while baboon cytokine/chemokine induction differed. Generally, responses were agonist independent. CONCLUSIONS: These primates tend to generate species rather than agonist-specific responses to bacterial agonists.
Authors: Gerard J Nau; Joan F L Richmond; Ann Schlesinger; Ezra G Jennings; Eric S Lander; Richard A Young Journal: Proc Natl Acad Sci U S A Date: 2002-01-22 Impact factor: 11.205
Authors: T K Means; B W Jones; A B Schromm; B A Shurtleff; J A Smith; J Keane; D T Golenbock; S N Vogel; M J Fenton Journal: J Immunol Date: 2001-03-15 Impact factor: 5.422
Authors: J A Langermans; P Andersen; D van Soolingen; R A Vervenne; P A Frost; T van der Laan; L A van Pinxteren; J van den Hombergh; S Kroon; I Peekel; S Florquin; A W Thomas Journal: Proc Natl Acad Sci U S A Date: 2001-09-18 Impact factor: 11.205
Authors: Jo Vandesompele; Katleen De Preter; Filip Pattyn; Bruce Poppe; Nadine Van Roy; Anne De Paepe; Frank Speleman Journal: Genome Biol Date: 2002-06-18 Impact factor: 13.583
Authors: Jonathan J Okerblom; Flavio Schwarz; Josh Olson; William Fletes; Syed Raza Ali; Paul T Martin; Christopher K Glass; Victor Nizet; Ajit Varki Journal: J Immunol Date: 2017-02-01 Impact factor: 5.422
Authors: Judith N Mandl; Rafi Ahmed; Luis B Barreiro; Peter Daszak; Jonathan H Epstein; Herbert W Virgin; Mark B Feinberg Journal: Cell Date: 2014-12-18 Impact factor: 41.582
Authors: William M Mitchell; Christopher F Nicodemus; William A Carter; Joseph C Horvath; David R Strayer Journal: Am J Pathol Date: 2014-01-30 Impact factor: 4.307
Authors: Mohamed B F Hawash; Joaquin Sanz-Remón; Jean-Christophe Grenier; Jordan Kohn; Vania Yotova; Zach Johnson; Robert E Lanford; Jessica F Brinkworth; Luis B Barreiro Journal: Proc Natl Acad Sci U S A Date: 2021-03-30 Impact factor: 11.205