PURPOSE: To evaluate the risk of developing Alzheimer disease (AD) or other dementia in patients diagnosed with open-angle glaucoma (OAG) in a nationally representative longitudinal sample of elderly persons. METHODS: This retrospective cohort study (January 1, 1994-December 31, 2007) used Medicare 5% claims data. We identified beneficiaries aged 68+ years who had at least two claims with diagnoses of OAG and no Alzheimer or other dementia in 1994, using a 3-year look-back period between 1991 and 1993 (n = 63,235) and beneficiaries matched on age, sex, race, and Charlson index without a diagnosis of OAG throughout the observational period (n = 63,235), using propensity score matching. Using a Cox Proportional Hazards model, we analyzed time to AD diagnosis and time to AD or other dementia diagnosis. RESULTS: Elderly individuals diagnosed with OAG did not have an increased rate of AD and other dementia diagnosis compared to those without OAG during a 14-year follow-up period, even after controlling for relevant covariates present at baseline. CONCLUSIONS: Individuals aged 68+ years diagnosed with OAG have a decreased rate of AD or other dementia diagnosis compared to control patients without an OAG diagnosis. Although OAG and AD are both age-related neurodegenerative diseases, our findings do not support a positive association.
PURPOSE: To evaluate the risk of developing Alzheimer disease (AD) or other dementia in patients diagnosed with open-angle glaucoma (OAG) in a nationally representative longitudinal sample of elderly persons. METHODS: This retrospective cohort study (January 1, 1994-December 31, 2007) used Medicare 5% claims data. We identified beneficiaries aged 68+ years who had at least two claims with diagnoses of OAG and no Alzheimer or other dementia in 1994, using a 3-year look-back period between 1991 and 1993 (n = 63,235) and beneficiaries matched on age, sex, race, and Charlson index without a diagnosis of OAG throughout the observational period (n = 63,235), using propensity score matching. Using a Cox Proportional Hazards model, we analyzed time to AD diagnosis and time to AD or other dementia diagnosis. RESULTS: Elderly individuals diagnosed with OAG did not have an increased rate of AD and other dementia diagnosis compared to those without OAG during a 14-year follow-up period, even after controlling for relevant covariates present at baseline. CONCLUSIONS: Individuals aged 68+ years diagnosed with OAG have a decreased rate of AD or other dementia diagnosis compared to control patients without an OAG diagnosis. Although OAG and AD are both age-related neurodegenerative diseases, our findings do not support a positive association.
Authors: S T Normand; M B Landrum; E Guadagnoli; J Z Ayanian; T J Ryan; P D Cleary; B J McNeil Journal: J Clin Epidemiol Date: 2001-04 Impact factor: 6.437
Authors: Philip D Sloane; Sheryl Zimmerman; Chirayath Suchindran; Peter Reed; Lily Wang; Malaz Boustani; S Sudha Journal: Annu Rev Public Health Date: 2001-10-25 Impact factor: 21.981
Authors: James C Vickers; Jamie E Craig; Jim Stankovich; Graeme H McCormack; Adrian K West; Joanne L Dickinson; Paul J McCartney; Michael A Coote; Danielle L Healey; David A Mackey Journal: Mol Vis Date: 2002-10-14 Impact factor: 2.367
Authors: Stuart J McKinnon; Donna M Lehman; Lisa A Kerrigan-Baumrind; Carol A Merges; Mary Ellen Pease; Danielle F Kerrigan; Nancy L Ransom; N Grace Tahzib; Herbert A Reitsamer; Hana Levkovitch-Verbin; Harry A Quigley; Donald J Zack Journal: Invest Ophthalmol Vis Sci Date: 2002-04 Impact factor: 4.799
Authors: Michelle L Baker; Jie Jin Wang; Sophie Rogers; Ronald Klein; Lewis H Kuller; Emily K Larsen; Tien Yin Wong Journal: Arch Ophthalmol Date: 2009-05
Authors: Cecilia S Lee; Eric B Larson; Laura E Gibbons; Aaron Y Lee; Susan M McCurry; James D Bowen; Wayne C McCormick; Paul K Crane Journal: Alzheimers Dement Date: 2018-08-08 Impact factor: 21.566
Authors: Phillip H Hwang; Will T Longstreth; Stephen M Thielke; Courtney E Francis; Marco Carone; Lewis H Kuller; Annette L Fitzpatrick Journal: Alzheimers Dement Date: 2021-03-31 Impact factor: 21.566
Authors: Aditya V Belamkar; Sasha A Mansukhani; Rodolfo Savica; Matthew R Spiegel; David O Hodge; Arthur J Sit Journal: J Glaucoma Date: 2021-03-01 Impact factor: 2.290