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Literature DB >> 22977657

The secret of FOXP3 downregulation in the inflammation condition.

Yang Li¹, Song Guo Zheng.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2012 PMID： 22977657 PMCID： PMC3438769

Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625

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15 in total

1. Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors.

Authors: Song Guo Zheng; J Dixon Gray; Kazuo Ohtsuka; Satoshi Yamagiwa; David A Horwitz
Journal: J Immunol Date: 2002-10-15 Impact factor: 5.422

2. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.

Authors: Estelle Bettelli; Yijun Carrier; Wenda Gao; Thomas Korn; Terry B Strom; Mohamed Oukka; Howard L Weiner; Vijay K Kuchroo
Journal: Nature Date: 2006-04-30 Impact factor: 49.962

3. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta.

Authors: Lili Xu; Atsushi Kitani; Ivan Fuss; Warren Strober
Journal: J Immunol Date: 2007-06-01 Impact factor: 5.422

4. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells.

Authors: Song Guo Zheng; Juhua Wang; Pu Wang; J Dixon Gray; David A Horwitz
Journal: J Immunol Date: 2007-02-15 Impact factor: 5.422

5. Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6.

Authors: Song Guo Zheng; Juhua Wang; David A Horwitz
Journal: J Immunol Date: 2008-06-01 Impact factor: 5.422

6. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

Authors: S Sakaguchi; N Sakaguchi; M Asano; M Itoh; M Toda
Journal: J Immunol Date: 1995-08-01 Impact factor: 5.422

The secret of FOXP3 downregulation in the inflammation condition.

1. Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors.

2. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.

3. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta.

4. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells.

5. Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6.

6. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

7. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.

8. Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells.

9. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.

10. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo.

1. Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing.

2. Supervised learning methods in modeling of CD4+ T cell heterogeneity.