Literature DB >> 22977552

Turmeric and curcumin suppress presenilin 1 protein expression in Jurkat cells.

Hitomi Yoshida1, Naoko Okumura, Yuri Nishimura, Yasuko Kitagishi, Satoru Matsuda.   

Abstract

In the present study, we aimed to determine the effects of herbs or spices on the expression of presenilin 1, a molecule involved in γ-secretase activity and the generation of amyloid-β peptide in Alzheimer's disease. Western blot analysis revealed that presenilin 1 protein expression was down-regulated by stimulation with turmeric or cinnamon extracts in vitro, while the effects on presenilin 1 gene expression examined by reverse transcriptase-polymerase chain reaction were unaltered. Our results showed that curcumin, a component of turmeric, induced the down-regulation of presenilin 1 protein in Jurkat and K562 cell lines.

Entities:  

Year:  2011        PMID： 22977552      PMCID： PMC3440695          DOI： 10.3892/etm.2011.246

Source DB:  PubMed          Journal:  Exp Ther Med        ISSN： 1792-0981            Impact factor:   2.447


  16 in total

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Review 2.  Genetics of Alzheimer disease.

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3.  Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.

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Review 4.  Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease.

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Journal:  Nat Rev Neurosci       Date:  2010-12-31       Impact factor: 34.870

5.  Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.

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6.  Fibroblasts from PS1 mutated pre-symptomatic subjects and Alzheimer's disease patients share a unique protein levels profile.

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7.  Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.

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8.  Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse.

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Journal:  Neurotox Res       Date:  2009-02-10       Impact factor: 3.911

9.  Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro.

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  7 in total

1.  Inhibitory effect of chloroquine derivatives on presenilin 1 and ubiquilin 1 expression in Alzheimer's disease.

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Journal:  Int J Clin Exp Pathol       Date:  2015-06-01

Review 2.  Diets involved in PPAR and PI3K/AKT/PTEN pathway may contribute to neuroprotection in a traumatic brain injury.

Authors:  Yasuko Kitagishi; Satoru Matsuda
Journal:  Alzheimers Res Ther       Date:  2013-09-26       Impact factor: 6.982

3.  Curcumin protects against lipopolysaccharide-induced vasoconstriction dysfunction via inhibition of thrombospondin-1 and transforming growth factor-β1.

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Journal:  Exp Ther Med       Date:  2014-12-03       Impact factor: 2.447

4.  Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum.

Authors:  Marco Cocorocchio; Amy J Baldwin; Balint Stewart; Lou Kim; Adrian J Harwood; Christopher R L Thompson; Paul L R Andrews; Robin S B Williams
Journal:  Dis Model Mech       Date:  2018-01-29       Impact factor: 5.758

Review 5.  Biopharmaceutical Monotargeting versus 'Universal Targeting' of Late-Onset Alzheimer's Disease Using Mixtures of Pleiotropic Natural Compounds.

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Journal:  J Alzheimers Dis Rep       Date:  2019-07-24

Review 6.  Curcumin Scaffold as a Multifunctional Tool for Alzheimer's Disease Research.

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Journal:  Molecules       Date:  2022-06-17       Impact factor: 4.927

Review 7.  Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression.

Authors:  Vishvanath Tiwari
Journal:  Phytomedicine       Date:  2018-09-26       Impact factor: 5.340
  7 in total

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