Literature DB >> 22977525

Tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44.

Kosuke Funato1, Yusuke Yamazumi, Takeaki Oda, Tetsu Akiyama.   

Abstract

PTPRD is a receptor-type tyrosine-protein phosphatase. Recent analyses of comprehensive mutations and copy numbers have revealed that PTPRD is frequently mutated and homozygously deleted in various types of cancer, including glioblastoma, melanoma, breast and colon cancer. However, the molecular functions of PTPRD in cancer progression have yet to be elucidated. Herein, PTPRD suppressed colon cancer cell migration and was required for appropriate cell-cell adhesion. In addition, PTPRD regulated cell migration in cooperation with β-catenin/TCF signaling and its target CD44. Furthermore, expression levels of PTPRD were down-regulated in highly invasive cancers and were significantly correlated with patient survival. Our findings suggest that PTPRD is required for colon cancer invasion and progression.

Entities:  

Year:  2011        PMID： 22977525      PMCID： PMC3440690          DOI： 10.3892/etm.2011.231

Source DB:  PubMed          Journal:  Exp Ther Med        ISSN： 1792-0981            Impact factor:   2.447


  38 in total

1.  Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice.

Authors:  N Uetani; K Kato; H Ogura; K Mizuno; K Kawano; K Mikoshiba; H Yakura; M Asano; Y Iwakura
Journal:  EMBO J       Date:  2000-06-15       Impact factor: 11.598

2.  Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer.

Authors:  Masamitsu Sato; Kenji Takahashi; Kazuhiro Nagayama; Yasuhito Arai; Nobue Ito; Mitsumasa Okada; John D Minna; Jun Yokota; Takashi Kohno
Journal:  Genes Chromosomes Cancer       Date:  2005-12       Impact factor: 5.006

3.  N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth.

Authors:  Roberta Siu; Chris Fladd; Daniela Rotin
Journal:  Mol Cell Biol       Date:  2006-10-23       Impact factor: 4.272

4.  Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

Authors:  A B Sparks; P J Morin; B Vogelstein; K W Kinzler
Journal:  Cancer Res       Date:  1998-03-15       Impact factor: 12.701

Review 5.  Wnt/beta-catenin signaling in cancer stemness and malignant behavior.

Authors:  Riccardo Fodde; Thomas Brabletz
Journal:  Curr Opin Cell Biol       Date:  2007-02-16       Impact factor: 8.382

6.  Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway.

Authors:  V J Wielenga; R Smits; V Korinek; L Smit; M Kielman; R Fodde; H Clevers; S T Pals
Journal:  Am J Pathol       Date:  1999-02       Impact factor: 4.307

Review 7.  Protein tyrosine phosphatase function: the substrate perspective.

Authors:  Tony Tiganis; Anton M Bennett
Journal:  Biochem J       Date:  2007-02-15       Impact factor: 3.857

8.  MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta.

Authors:  Jacquelyn A Woodings; Stewart J Sharp; Laura M Machesky
Journal:  Biochem J       Date:  2003-04-15       Impact factor: 3.857

9.  Transactivation of vimentin by beta-catenin in human breast cancer cells.

Authors:  Christine Gilles; Myriam Polette; Mélanie Mestdagt; Béatrice Nawrocki-Raby; Philippe Ruggeri; Philippe Birembaut; Jean-Michel Foidart
Journal:  Cancer Res       Date:  2003-05-15       Impact factor: 12.701

10.  Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer.

Authors:  Danijela Vignjevic; Marie Schoumacher; Nancy Gavert; Klaus-Peter Janssen; Gloria Jih; Marick Laé; Daniel Louvard; Avri Ben-Ze'ev; Sylvie Robine
Journal:  Cancer Res       Date:  2007-07-15       Impact factor: 12.701
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  21 in total

1.  Integrated Genomics for Pinpointing Survival Loci within Arm-Level Somatic Copy Number Alterations.

Authors:  David M Roy; Logan A Walsh; Alexis Desrichard; Jason T Huse; Wei Wu; JianJiong Gao; Promita Bose; William Lee; Timothy A Chan
Journal:  Cancer Cell       Date:  2016-05-09       Impact factor: 31.743

2.  Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma.

Authors:  Vijay Walia; Todd D Prickett; Jung-Sik Kim; Jared J Gartner; Jimmy C Lin; Ming Zhou; Steven A Rosenberg; Randolph C Elble; David A Solomon; Todd Waldman; Yardena Samuels
Journal:  Hum Mutat       Date:  2014-09-10       Impact factor: 4.878

3.  Loss of Tyrosine Phosphatase Delta Promotes Gastric Cancer Progression via Signal Transducer and Activator of Transcription 3 Pathways.

Authors:  Lei Wu; Lanying Gao; Decai Kong; Hongfeng Xue
Journal:  Dig Dis Sci       Date:  2019-04-30       Impact factor: 3.199

4.  The Non-Receptor Protein Tyrosine Phosphatase PTPN6 Mediates a Positive Regulatory Approach From the Interferon Regulatory Factor to the JAK/STAT Pathway in Litopenaeus vannamei.

Authors:  Mengting Luo; Xiaopeng Xu; Xinxin Liu; Wenjie Shen; Linwei Yang; Zhiming Zhu; Shaoping Weng; Jianguo He; Hongliang Zuo
Journal:  Front Immunol       Date:  2022-06-29       Impact factor: 8.786

5.  Unbiased identification of substrates of protein tyrosine phosphatase ptp-3 in C. elegans.

Authors:  Christopher J Mitchell; Min-Sik Kim; Jun Zhong; Raja Sekhar Nirujogi; Anjun K Bose; Akhilesh Pandey
Journal:  Mol Oncol       Date:  2016-03-25       Impact factor: 6.603

Review 6.  Genetic alterations of protein tyrosine phosphatases in human cancers.

Authors:  S Zhao; D Sedwick; Z Wang
Journal:  Oncogene       Date:  2014-09-29       Impact factor: 9.867

7.  Theranostic Profiling for Actionable Aberrations in Advanced High Risk Osteosarcoma with Aggressive Biology Reveals High Molecular Diversity: The Human Fingerprint Hypothesis.

Authors:  Daniela Egas-Bejar; Pete M Anderson; Rishi Agarwal; Fernando Corrales-Medina; Eswaran Devarajan; Winston W Huh; Robert E Brown; Vivek Subbiah
Journal:  Oncoscience       Date:  2014-03-12

8.  A recellularized human colon model identifies cancer driver genes.

Authors:  Huanhuan Joyce Chen; Zhubo Wei; Jian Sun; Asmita Bhattacharya; David J Savage; Rita Serda; Yuri Mackeyev; Steven A Curley; Pengcheng Bu; Lihua Wang; Shuibing Chen; Leona Cohen-Gould; Emina Huang; Xiling Shen; Steven M Lipkin; Neal G Copeland; Nancy A Jenkins; Michael L Shuler
Journal:  Nat Biotechnol       Date:  2016-07-11       Impact factor: 54.908

9.  Protein tyrosine phosphatase receptor-type δ acts as a negative regulator suppressing breast cancer.

Authors:  Xiaotang Yu; Fan Zhang; Jun Mao; Ying Lu; Jiazhi Li; Wei Ma; Shujun Fan; Chunying Zhang; Qing Li; Bo Wang; Bo Song; Lianhong Li
Journal:  Oncotarget       Date:  2017-10-24

10.  Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility.

Authors:  Hui-Min Zhou; Yuan-Yuan Fang; Paul M Weinberger; Ling-Ling Ding; John K Cowell; Farlyn Z Hudson; Mingqiang Ren; Jeffrey R Lee; Qi-Kui Chen; Hong Su; William S Dynan; Ying Lin
Journal:  BMC Cancer       Date:  2016-02-04       Impact factor: 4.430
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