| Literature DB >> 22976543 |
Helenisa Helena Oliveira-Neto1, Pedro Paulo Chaves de Souza, Márcio Roberto Barbosa da Silva, Elismauro Francisco Mendonça, Tarcília Aparecida Silva, Aline Carvalho Batista.
Abstract
The purpose of this study is to determine the expression of CCL19, CCL21, and CCR7 in samples of oral squamous cell carcinoma (OSCC) and their relationship with clinical and microscopic parameters. A comparative analysis was made of the mRNA expression of these chemokines and receptor in OSCC and normal oral mucosa. The immunoexpression of CCR7, CCL19, and CCL21 was also verified in OSCC and lymph nodes. Statistical significance was accepted at P < 0.05. Similar levels of CCR7, CCL19, and CCL21 mRNA in OSCC and normal oral mucosa were seen. A low expression of CCL19 and CCL21 in the intra- and peritumoral regions was observed. Scarce CCL19(+) and CCL21(+) cells were also noted in metastatic and non-metastatic lymph nodes. No association was found between the expression of these chemokines and clinical and microscopic parameters. Our findings would suggest that CCL19 and CCL21 may not be associated with cervical lymph node metastasis or other clinical and microscopic factors in OSCC.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22976543 DOI： 10.1007/s13277-012-0511-3
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283