| Literature DB >> 22976180 |
Mikhail Ryzhikov1, Sergey Korolev.
Abstract
Interaction of recombination protein RecO with single-stranded (ss) DNA-binding protein (SSB) is essential for DNA damage repair and restart of stalled replication (Cox, Crit Rev Biochem Mol Biol 42(1):41-63, 2007). To understand mechanism of this interaction and its role in DNA repair, we deciphered a high-resolution structure of RecO complex with C-terminal tail of SSB (SSB-Ct). The structure revealed a key role of hydrophobic interactions between two proteins and suggests the mechanism of RecO recruitment to DNA during homologous recombination and strand annealing.Entities:
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Year: 2012 PMID： 22976180 DOI： 10.1007/978-1-62703-032-8_7
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745