Literature DB >> 22975370

Strategies for p53 reactivation in human sarcoma.

Ted R Hupp1, Richard L Hayward, Borek Vojtesek.   

Abstract

Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for reactivation of p53 in human sarcoma.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22975370     DOI： 10.1016/j.ccr.2012.08.020

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  6 in total

1.  In silico prediction of physical protein interactions and characterization of interactome orphans.

Authors:  Max Kotlyar; Chiara Pastrello; Flavia Pivetta; Alessandra Lo Sardo; Christian Cumbaa; Han Li; Taline Naranian; Yun Niu; Zhiyong Ding; Fatemeh Vafaee; Fiona Broackes-Carter; Julia Petschnigg; Gordon B Mills; Andrea Jurisicova; Igor Stagljar; Roberta Maestro; Igor Jurisica
Journal:  Nat Methods       Date:  2014-11-17       Impact factor: 28.547

2.  Association between p53 codon 72 polymorphism and sarcoma risk among Caucasians.

Authors:  Zhengqi Chang; Xiuchun Yu
Journal:  Tumour Biol       Date:  2014-01-22

3.  Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice.

Authors:  Shideh Kazerounian; Pedro D S C Ciarlini; Daniel Yuan; Roxanne Ghazvinian; Meritxell Alberich-Jorda; Mugdha Joshi; Hong Zhang; Alan H Beggs; Hanna T Gazda
Journal:  J Cancer       Date:  2016-01-01       Impact factor: 4.207

Review 4.  Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex.

Authors:  Giovanna Carrà; Sabrina Crivellaro; Riccardo Taulli; Angelo Guerrasio; Giuseppe Saglio; Alessandro Morotti
Journal:  Int J Mol Sci       Date:  2016-11-29       Impact factor: 5.923

Review 5.  Molecular and Biochemical Techniques for Deciphering p53-MDM2 Regulatory Mechanisms.

Authors:  Konstantinos Karakostis; Ignacio López; Ana M Peña-Balderas; Robin Fåhareus; Vanesa Olivares-Illana
Journal:  Biomolecules       Date:  2020-12-30

Review 6.  Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes.

Authors:  Albert E Berman; Olga V Leontieva; Venkatesh Natarajan; James A McCubrey; Zoya N Demidenko; Mikhail A Nikiforov
Journal:  Oncotarget       Date:  2012-12
  6 in total

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