Literature DB >> 22975001

Studies on Aplysia neurons suggest treatments for chronic human disorders.

Thomas W Abrams1.   

Abstract

For decades, the marine snail Aplysia has proven to be a powerful system for analyzing basic neurobiological mechanisms, particularly cellular and molecular mechanisms of neural plasticity. Three new findings on Aplysia may be relevant for the understanding and treatment of chronic human disorders. This research on this simple molluscan nervous system may lead to new therapeutic approaches for spinal cord injury, Fragile X syndrome, and genetic learning deficits more generally.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID: 22975001      PMCID: PMC9279012          DOI: 10.1016/j.cub.2012.08.011

Source DB:  PubMed          Journal:  Curr Biol        ISSN: 0960-9822            Impact factor:   10.900


  20 in total

1.  Serotonin regulates the secretion and autocrine action of a neuropeptide to activate MAPK required for long-term facilitation in Aplysia.

Authors:  Jiang-Yuan Hu; Leonard Glickman; Fang Wu; Samuel Schacher
Journal:  Neuron       Date:  2004-08-05       Impact factor: 17.173

Review 2.  Toward fulfilling the promise of molecular medicine in fragile X syndrome.

Authors:  Dilja D Krueger; Mark F Bear
Journal:  Annu Rev Med       Date:  2011       Impact factor: 13.739

3.  Long-term enhancement produced by activity-dependent modulation of Aplysia sensory neurons.

Authors:  E T Walters; J H Byrne
Journal:  J Neurosci       Date:  1985-03       Impact factor: 6.167

4.  Induction of a cellular defense reaction is accompanied by an increase in sensory neuron excitability in Aplysia.

Authors:  A L Clatworthy; G A Castro; B U Budelmann; E T Walters
Journal:  J Neurosci       Date:  1994-05       Impact factor: 6.167

5.  Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity.

Authors:  A N Hegde; A L Goldberg; J H Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-15       Impact factor: 11.205

6.  In Aplysia sensory neurons, the neuropeptide SCPB and serotonin differ in efficacy both in modulating cellular properties and in activating adenylyl cyclase: implications for mechanisms underlying presynaptic facilitation.

Authors:  H E Jarrard; B A Goldsmith; T W Abrams
Journal:  Brain Res       Date:  1993-07-09       Impact factor: 3.252

7.  Long-lasting hyperexcitability induced by depolarization in the absence of detectable Ca2+ signals.

Authors:  Kumud K Kunjilwar; Harvey M Fishman; Dario J Englot; Roger G O'Neil; Edgar T Walters
Journal:  J Neurophysiol       Date:  2009-01-14       Impact factor: 2.714

8.  Transient mitogen-activated protein kinase activation is confined to a narrow temporal window required for the induction of two-trial long-term memory in Aplysia.

Authors:  Gary T Philips; Ekaterina I Tzvetkova; Thomas J Carew
Journal:  J Neurosci       Date:  2007-12-12       Impact factor: 6.167

9.  Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels.

Authors:  Yalan Zhang; Maile R Brown; Callen Hyland; Yi Chen; Jack Kronengold; Matthew R Fleming; Andrea B Kohn; Leonid L Moroz; Leonard K Kaczmarek
Journal:  J Neurosci       Date:  2012-10-31       Impact factor: 6.167

10.  Computational design of enhanced learning protocols.

Authors:  Yili Zhang; Rong-Yu Liu; George A Heberton; Paul Smolen; Douglas A Baxter; Leonard J Cleary; John H Byrne
Journal:  Nat Neurosci       Date:  2011-12-25       Impact factor: 24.884

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  12 in total

1.  Proteasome regulates the mediators of cytoplasmic polyadenylation signaling during late-phase long-term potentiation.

Authors:  Chenghai Dong; Anirudh Vashisht; Ashok N Hegde
Journal:  Neurosci Lett       Date:  2014-09-28       Impact factor: 3.046

2.  Enrofloxacin Pharmacokinetics and Sampling Techniques in California Sea Hares (Aplysia californica).

Authors:  Sharon E Mason; Mark G Papich; Michael C Schmale; Craig A Harms; Sally A Davis
Journal:  J Am Assoc Lab Anim Sci       Date:  2019-02-28       Impact factor: 1.232

Review 3.  Using C. elegans to decipher the cellular and molecular mechanisms underlying neurodevelopmental disorders.

Authors:  Carlos Bessa; Patrícia Maciel; Ana João Rodrigues
Journal:  Mol Neurobiol       Date:  2013-03-14       Impact factor: 5.590

4.  Protein phosphatase-dependent circadian regulation of intermediate-term associative memory.

Authors:  Maximilian Michel; Jacob S Gardner; Charity L Green; Chelsea L Organ; Lisa C Lyons
Journal:  J Neurosci       Date:  2013-03-06       Impact factor: 6.167

Review 5.  Local ubiquitin-proteasome-mediated proteolysis and long-term synaptic plasticity.

Authors:  Ashok N Hegde; Kathryn A Haynes; Svitlana V Bach; Brenna C Beckelman
Journal:  Front Mol Neurosci       Date:  2014-12-01       Impact factor: 5.639

Review 6.  Unraveling the complexities of circadian and sleep interactions with memory formation through invertebrate research.

Authors:  Maximilian Michel; Lisa C Lyons
Journal:  Front Syst Neurosci       Date:  2014-08-04

7.  A d-Amino Acid-Containing Neuropeptide Discovery Funnel.

Authors:  Itamar Livnat; Hua-Chia Tai; Erik T Jansson; Lu Bai; Elena V Romanova; Ting-Ting Chen; Ke Yu; Song-An Chen; Yan Zhang; Zheng-Yang Wang; Dan-Dan Liu; Klaudiusz R Weiss; Jian Jing; Jonathan V Sweedler
Journal:  Anal Chem       Date:  2016-11-10       Impact factor: 6.986

8.  Immediate and persistent transcriptional correlates of long-term sensitization training at different CNS loci in Aplysia californica.

Authors:  Samantha Herdegen; Catherine Conte; Saman Kamal; Robert J Calin-Jageman; Irina E Calin-Jageman
Journal:  PLoS One       Date:  2014-12-08       Impact factor: 3.240

9.  Aplysia Locomotion: Network and Behavioral Actions of GdFFD, a D-Amino Acid-Containing Neuropeptide.

Authors:  Chao-Yu Yang; Ke Yu; Ye Wang; Song-An Chen; Dan-Dan Liu; Zheng-Yang Wang; Yan-Nan Su; Shao-Zhong Yang; Ting-Ting Chen; Itamar Livnat; Ferdinand S Vilim; Elizabeth C Cropper; Klaudiusz R Weiss; Jonathan V Sweedler; Jian Jing
Journal:  PLoS One       Date:  2016-01-21       Impact factor: 3.240

Review 10.  Modeling Fragile X Syndrome in Drosophila.

Authors:  Małgorzata Drozd; Barbara Bardoni; Maria Capovilla
Journal:  Front Mol Neurosci       Date:  2018-04-16       Impact factor: 5.639

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