BACKGROUND: There are still many controversies about the impact of delayed graft function (DGF) on kidney transplantation outcome. The aims of this study were to define factors associated with DGF and to ascertain the relative impact of DGF on kidney transplantation outcome, both in the early postoperative period and in long-term follow-up. PATIENTS AND METHODS: Four hundred kidney transplant recipients were reviewed to assess the clinical impact of DGF on long-term outcome. RESULTS: The overall prevalence of DGF was 24.3%. DGF was significantly associated with increasing recipient and donor age, duration of dialysis, and cold ischemia time. Patients with DGF displayed a significantly worse graft (P = .005) and patient (P < .001) survival compared with recipients with immediate function. CONCLUSION: DGF is a frequent complication of renal transplantation and may be associated with a reduced graft and even patient survival. Strategies to prevent graft injury and, more specifically, DGF may be an important clue to provide a better long-term outcome in kidney transplantation.
BACKGROUND: There are still many controversies about the impact of delayed graft function (DGF) on kidney transplantation outcome. The aims of this study were to define factors associated with DGF and to ascertain the relative impact of DGF on kidney transplantation outcome, both in the early postoperative period and in long-term follow-up. PATIENTS AND METHODS: Four hundred kidney transplant recipients were reviewed to assess the clinical impact of DGF on long-term outcome. RESULTS: The overall prevalence of DGF was 24.3%. DGF was significantly associated with increasing recipient and donor age, duration of dialysis, and cold ischemia time. Patients with DGF displayed a significantly worse graft (P = .005) and patient (P < .001) survival compared with recipients with immediate function. CONCLUSION: DGF is a frequent complication of renal transplantation and may be associated with a reduced graft and even patient survival. Strategies to prevent graft injury and, more specifically, DGF may be an important clue to provide a better long-term outcome in kidney transplantation.
Authors: Bret M Verhoven; Aos S Karim; Natalie M Bath; Carol J Sarabia Fahl; Nancy A Wilson; Robert R Redfield; William E Fahl Journal: Transplant Direct Date: 2020-07-15
Authors: Chang Ho Seo; Jeong Il Ju; Mi-Hyeong Kim; Kang Woong Jun; Sang-Hyun Ahn; Jeong Kye Hwang; Sang Dong Kim; Sun Cheol Park; Bum Soon Choi; Ji Il Kim; Chul Woo Yang; Yong Soo Kim; In Sung Moon Journal: Ann Surg Treat Res Date: 2015-09-25 Impact factor: 1.859
Authors: Sofia Nordling; Johan Brännström; Fredrik Carlsson; Bo Lu; Evelyn Salvaris; Alkwin Wanders; Jos Buijs; Sergio Estrada; Vladimir Tolmachev; Peter J Cowan; Tomas Lorant; Peetra U Magnusson Journal: Sci Rep Date: 2018-03-26 Impact factor: 4.379