Literature DB >> 22973426

OPTIMIZING DIAGNOSIS AND MANANGEMENT IN MILD-TO-MODERATE ALZHEIMER'S DISEASE.

James E Galvin1.   

Abstract

Alzheimer's disease (AD) is characterized by progressive declines in cognitive function and ability to carry out activities of daily living; and the emergence and worsening of behavioral/neuropsychiatric symptoms. While there is no cure for AD, non-pharmacologic interventions and medications that modulate neurotransmission can slow symptomatic progression. Medical foods may also be useful as adjuncts to pharmacologic agents in AD. Medium chain triglycerides aimed at improving cerebral metabolism significantly improve Alzheimer's Disease Assessment Scale-Cognitive scores when added to ongoing pharmacotherapy in patients with mild-to-moderate AD. Combination of interventions, such as non-pharmacologic treatments, pharmacotherapy, and medical foods, with complementary mechanisms of action may provide a rational approach that may result in maximum preservation of cognitive function in patients with AD.

Entities:  

Year:  2012        PMID: 22973426      PMCID: PMC3437664          DOI: 10.2217/nmt.12.21

Source DB:  PubMed          Journal:  Neurodegener Dis Manag        ISSN: 1758-2024


  96 in total

Review 1.  Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.

Authors:  David W Klaver; Matthew C J Wilce; Hao Cui; Amos C Hung; Robert Gasperini; Lisa Foa; David H Small
Journal:  Biol Chem       Date:  2010-08       Impact factor: 3.915

2.  High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study.

Authors:  Katherine L Tucker; Ning Qiao; Tammy Scott; Irwin Rosenberg; Avron Spiro
Journal:  Am J Clin Nutr       Date:  2005-09       Impact factor: 7.045

Review 3.  Are anti-angiogenic drugs useful in neurodegenerative disorders?

Authors:  Daniele De Filippis; Mariateresa Cipriano; Giuseppe Esposito; Caterina Scuderi; Luca Steardo; Teresa Iuvone
Journal:  CNS Neurol Disord Drug Targets       Date:  2010-12       Impact factor: 4.388

4.  Local MRI analysis approach in the diagnosis of early and prodromal Alzheimer's disease.

Authors:  Andrea Chincarini; Paolo Bosco; Piero Calvini; Gianluca Gemme; Mario Esposito; Chiara Olivieri; Luca Rei; Sandro Squarcia; Guido Rodriguez; Roberto Bellotti; Piergiorgio Cerello; Ivan De Mitri; Alessandra Retico; Flavio Nobili
Journal:  Neuroimage       Date:  2011-06-16       Impact factor: 6.556

5.  Behavioral and neuropsychiatric outcomes in Alzheimer's disease.

Authors:  Jeffrey L Cummings
Journal:  CNS Spectr       Date:  2005-11       Impact factor: 3.790

Review 6.  Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease.

Authors:  Lisa Mosconi; Alberto Pupi; Mony J De Leon
Journal:  Ann N Y Acad Sci       Date:  2008-12       Impact factor: 5.691

7.  Long-term course and effectiveness of combination therapy in Alzheimer disease.

Authors:  Alireza Atri; Lynn W Shaughnessy; Joseph J Locascio; John H Growdon
Journal:  Alzheimer Dis Assoc Disord       Date:  2008 Jul-Sep       Impact factor: 2.703

Review 8.  Targeting Abeta and tau in Alzheimer's disease, an early interim report.

Authors:  Todd E Golde; Leonard Petrucelli; Jada Lewis
Journal:  Exp Neurol       Date:  2009-08-27       Impact factor: 5.330

Review 9.  Management of behavioral problems in Alzheimer's disease.

Authors:  Serge Gauthier; Jeffrey Cummings; Clive Ballard; Henry Brodaty; George Grossberg; Philippe Robert; Constantine Lyketsos
Journal:  Int Psychogeriatr       Date:  2010-01-25       Impact factor: 3.878

10.  A comparison of the mini mental state exam to the Montreal cognitive assessment in identifying cognitive deficits in Parkinson's disease.

Authors:  Cindy Zadikoff; Susan H Fox; David F Tang-Wai; Teri Thomsen; Rob M A de Bie; Pettarusup Wadia; Janis Miyasaki; Sarah Duff-Canning; Anthony E Lang; Connie Marras
Journal:  Mov Disord       Date:  2008-01-30       Impact factor: 10.338

View more
  4 in total

Review 1.  A practical algorithm for managing Alzheimer's disease: what, when, and why?

Authors:  Jeffrey L Cummings; Richard S Isaacson; Frederick A Schmitt; Drew M Velting
Journal:  Ann Clin Transl Neurol       Date:  2015-01-23       Impact factor: 4.511

2.  Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model.

Authors:  Csilla Ari; Angela M Poff; Heather E Held; Carol S Landon; Craig R Goldhagen; Nicholas Mavromates; Dominic P D'Agostino
Journal:  PLoS One       Date:  2014-07-25       Impact factor: 3.240

3.  Using Informant and Performance Screening Methods to Detect Mild Cognitive Impairment and Dementia.

Authors:  James E Galvin
Journal:  Curr Geriatr Rep       Date:  2018-01-26

Review 4.  Abnormal Homocysteine Metabolism: An Insight of Alzheimer's Disease from DNA Methylation.

Authors:  Tingting Pi; Bo Liu; Jingshan Shi
Journal:  Behav Neurol       Date:  2020-09-08       Impact factor: 3.342

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.