| Literature DB >> 2297316 |
P R Badenoch1, A M Johnson, P E Christy, D J Coster.
Abstract
Acanthamoeba keratitis is a sight-threatening disease that is difficult to treat. The development of an animal model is necessary for many of the studies required to improve visual outcome in human patients. A rat model is proposed that is dependent on coinoculation of amebae and corynebacteria into the corneal stroma. The infective dose was determined for a virulent Acanthamoeba isolate and was used to screen 17 other isolates, including 7 from the human cornea. A total of 6 were infective in the rat cornea. The model should be useful for controlled in vivo studies of this intractable condition.Entities:
Mesh：
Year: 1990 PMID： 2297316 DOI： 10.1001/archopht.1990.01070030113040
Source DB: PubMed Journal: Arch Ophthalmol ISSN： 0003-9950