Literature DB >> 22972841

Extrapolating from animals to humans.

John P A Ioannidis1.   

Abstract

Because of a variety of caveats, the safety and effectiveness of interventions in human subjects can only be speculated from animal studies. Careful synthesis of data from multiple animal studies is needed to begin to assess the likelihood of successful cross-species translation (Fay et al., this issue).

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Year:  2012        PMID： 22972841     DOI： 10.1126/scitranslmed.3004631

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  41 in total

1.  Models of Human AKI: Resemblance, Reproducibility, and Return on Investment.

Authors:  Karl A Nath
Journal:  J Am Soc Nephrol       Date:  2015-11-04       Impact factor: 10.121

Review 2.  Critical evaluation of challenges and future use of animals in experimentation for biomedical research.

Authors:  Vijay Pal Singh; Kunal Pratap; Juhi Sinha; Koundinya Desiraju; Devika Bahal; Ritushree Kukreti
Journal:  Int J Immunopathol Pharmacol       Date:  2016-09-30       Impact factor: 3.219

Review 3.  Power failure: why small sample size undermines the reliability of neuroscience.

Authors:  Katherine S Button; John P A Ioannidis; Claire Mokrysz; Brian A Nosek; Jonathan Flint; Emma S J Robinson; Marcus R Munafò
Journal:  Nat Rev Neurosci       Date:  2013-04-10       Impact factor: 34.870

4.  Prolonged uterine artery nitric oxide synthase inhibition modestly alters basal uteroplacental vasodilation in the last third of ovine pregnancy.

Authors:  Charles R Rosenfeld; Timothy Roy
Journal:  Am J Physiol Heart Circ Physiol       Date:  2014-08-15       Impact factor: 4.733

5.  Mathematical model of liver regeneration in human live donors.

Authors:  V Periwal; J R Gaillard; L Needleman; C Doria
Journal:  J Cell Physiol       Date:  2014-05       Impact factor: 6.384

6.  Importance of Systematic Reviews and Meta-analyses of Animal Studies: Challenges for Animal-to-Human Translation.

Authors:  Zahra Bahadoran; Parvin Mirmiran; Khosrow Kashfi; Asghar Ghasemi
Journal:  J Am Assoc Lab Anim Sci       Date:  2020-07-29       Impact factor: 1.232

Review 7.  The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.

Authors:  O Friedrich; M B Reid; G Van den Berghe; I Vanhorebeek; G Hermans; M M Rich; L Larsson
Journal:  Physiol Rev       Date:  2015-07       Impact factor: 37.312

Review 8.  Improving the predictive value of interventional animal models data.

Authors:  Caroline J Zeiss
Journal:  Drug Discov Today       Date:  2014-11-04       Impact factor: 7.851

9.  Comparison of Aerosol- and Percutaneous-acquired Venezuelan Equine Encephalitis in Humans and Nonhuman Primates for Suitability in Predicting Clinical Efficacy under the Animal Rule.

Authors:  Janice M Rusnak; Lesley C Dupuy; Nancy A Niemuth; Andrew M Glenn; Lucy A Ward
Journal:  Comp Med       Date:  2018-10-03       Impact factor: 0.982

10.  Look back in anger - what clinical studies tell us about preclinical work.

Authors:  Thomas Hartung
Journal:  ALTEX       Date:  2013       Impact factor: 6.043
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