Literature DB >> 22972723

Health Canada advisory on domperidone should I avoid prescribing domperidone to women to increase milk production [corrected]?

Pina Bozzo, Gideon Koren, Shinya Ito.   

Abstract

QUESTION: I often prescribe domperidone to women as a galactagogue starting at a dose of 30 mg and increasing the dose as needed. In March of this year, Health Canada released an advisory warning of domperidone use and abnormal heart rhythms and sudden cardiac death. Should I cap doses at 30 mg or stop prescribing domperidone all together to these women? ANSWER: The Health Canada warning is based on 2 studies. The results of the studies are not directly applicable to breastfeeding and should not change the way you normally manage otherwise healthy breastfeeding women.

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Year:  2012        PMID: 22972723      PMCID: PMC3440266     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN: 0008-350X            Impact factor:   3.275


  7 in total

1.  Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands.

Authors:  Charlotte van Noord; Jeanne P Dieleman; Gerard van Herpen; Katia Verhamme; Miriam C J M Sturkenboom
Journal:  Drug Saf       Date:  2010-11-01       Impact factor: 5.606

2.  Effect of domperidone on milk production in mothers of premature newborns: a randomized, double-blind, placebo-controlled trial.

Authors:  O P da Silva; D C Knoppert; M M Angelini; P A Forret
Journal:  CMAJ       Date:  2001-01-09       Impact factor: 8.262

3.  Effects of domperidone on augmentation of lactation following cesarean delivery at full term.

Authors:  Surasak Jantarasaengaram; Praweena Sreewapa
Journal:  Int J Gynaecol Obstet       Date:  2011-12-20       Impact factor: 3.561

4.  Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control study.

Authors:  Catherine B Johannes; Cristina Varas-Lorenzo; Lisa J McQuay; Kirk D Midkiff; Daniel Fife
Journal:  Pharmacoepidemiol Drug Saf       Date:  2010-09       Impact factor: 2.890

5.  Domperidone in defective and insufficient lactation.

Authors:  F Petraglia; V De Leo; S Sardelli; M L Pieroni; N D'Antona; A R Genazzani
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  1985-05       Impact factor: 2.435

6.  Domperidone: secretion in breast milk and effect on puerperal prolactin levels.

Authors:  G J Hofmeyr; B Van Iddekinge; J A Blott
Journal:  Br J Obstet Gynaecol       Date:  1985-02

7.  Effect of domperidone on insufficient lactation in puerperal women: a systematic review and meta-analysis of randomized controlled trials.

Authors:  Alla Osadchy; Myla E Moretti; Gideon Koren
Journal:  Obstet Gynecol Int       Date:  2012-02-07
  7 in total
  7 in total

Review 1.  A Review of Herbal and Pharmaceutical Galactagogues for Breast-Feeding.

Authors:  Alessandra N Bazzano; Rebecca Hofer; Shelley Thibeau; Veronica Gillispie; Marni Jacobs; Katherine P Theall
Journal:  Ochsner J       Date:  2016

Review 2.  Domperidone-Associated QT Interval Prolongation in Non-oncologic Pediatric Patients: A Review of the Literature.

Authors:  Amy D Morris; Jennifer Chen; Elaine Lau; Jennifer Poh
Journal:  Can J Hosp Pharm       Date:  2016-06-30

Review 3.  Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis.

Authors:  Nattawut Leelakanok; Andrea Holcombe; Marin L Schweizer
Journal:  Clin Drug Investig       Date:  2016-02       Impact factor: 2.859

4.  Postpartum domperidone use in British Columbia: a retrospective cohort study.

Authors:  Kate Smolina; Steven G Morgan; Gillian E Hanley; Tim F Oberlander; Barbara Mintzes
Journal:  CMAJ Open       Date:  2016-01-12

5.  Effect of acupressure on milk volume of breastfeeding mothers referring to selected health care centers in Tehran.

Authors:  Mitra Savabi Esfahani; Shohreh Berenji-Sooghe; Mahboubeh Valiani; Soheila Ehsanpour
Journal:  Iran J Nurs Midwifery Res       Date:  2015 Jan-Feb

6.  Health provider experiences with galactagogues to support breastfeeding: a cross-sectional survey.

Authors:  Alessandra N Bazzano; Lisa Littrell; Amelia Brandt; Shelley Thibeau; Kamala Thriemer; Katherine P Theall
Journal:  J Multidiscip Healthc       Date:  2016-11-17

Review 7.  Management of dysphagia and gastroparesis in Parkinson's disease in real-world clinical practice - Balancing pharmacological and non-pharmacological approaches.

Authors:  Roongroj Bhidayasiri; Warongporn Phuenpathom; Ai Huey Tan; Valentina Leta; Saisamorn Phumphid; K Ray Chaudhuri; Pramod Kumar Pal
Journal:  Front Aging Neurosci       Date:  2022-08-11       Impact factor: 5.702

  7 in total

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