Literature DB >> 22972347

Physiological effects and tissue distribution from large doses of tocotrienol in rats.

Akira Shibata1, Kiyotaka Nakagawa, Hitoshi Shirakawa, Teiko Kobayashi, Yuki Kawakami, Rie Takashima, Ai Ohashi, Shoko Sato, Yusuke Ohsaki, Fumiko Kimura, Toshiyuki Kimura, Tsuyoshi Tsuduki, Michio Komai, Teruo Miyazawa.   

Abstract

Supplementation to an AIN93G-based diet of tocotrienol (T3) for 13 weeks administered to Fischer 344/slc rats showed a safety profile with no side effects. Dose-dependent T3 levels were detected in many tissues. Under the present experimental conditions, a continuous intake of the T3 concentrate would be safe in the rats as long as the T3 content was less than 0.20% of the dietary intake.

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Year:  2012        PMID: 22972347     DOI: 10.1271/bbb.120387

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN: 0916-8451            Impact factor:   2.043


  4 in total

1.  Gamma-tocotrienol attenuates high-fat diet-induced obesity and insulin resistance by inhibiting adipose inflammation and M1 macrophage recruitment.

Authors:  L Zhao; I Kang; X Fang; W Wang; M A Lee; R R Hollins; M R Marshall; S Chung
Journal:  Int J Obes (Lond)       Date:  2014-07-21       Impact factor: 5.095

2.  Anti-inflammatory γ- and δ-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats.

Authors:  Weng-Yew Wong; Leigh C Ward; Chee Wai Fong; Wei Ney Yap; Lindsay Brown
Journal:  Eur J Nutr       Date:  2015-10-08       Impact factor: 5.614

3.  Autophagy inhibitor 3-methyladenine potentiates apoptosis induced by dietary tocotrienols in breast cancer cells.

Authors:  Anh Thu Tran; Malathi Ramalinga; Habib Kedir; Robert Clarke; Deepak Kumar
Journal:  Eur J Nutr       Date:  2014-05-16       Impact factor: 5.614

Review 4.  Tocotrienols: Dietary Supplements for Chronic Obstructive Pulmonary Disease.

Authors:  Xiangming Ji; Hongwei Yao; Maureen Meister; Douglas S Gardenhire; Huanbiao Mo
Journal:  Antioxidants (Basel)       Date:  2021-05-31
  4 in total

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