BACKGROUND: The treatment of localized esophageal cancer has been debated controversially over the past decades. Neoadjuvant treatment was used empirically, but evidence was limited due to the lack of high-quality confirmatory studies. Meanwhile, data have become much clearer due to recently published well-conducted randomized controlled trials and meta-analyses. METHODS: Neoadjuvant and perioperative platinum fluoropyrimidine-based combination chemotherapy has now an established role in the treatment of stage II and stage III esophageal adenocarcinoma and cancer of the esophago-gastric junction. Neoadjuvant chemoradiation is now the standard of care for treating stage II and stage III esophageal squamous cell cancer and can also be considered for treating esophageal adenocarcinoma. RESULTS: Patients with esophageal squamous cell cancer treated with definitive chemoradiation achieve comparable long-term survival compared with surgery. Short-term mortality is less with chemoradiation alone, but local tumor control is significantly better with surgery. CONCLUSION: This expert review article outlines current data and literature and delineates recommendable treatment guidelines for localized esophageal cancer.
BACKGROUND: The treatment of localized esophageal cancer has been debated controversially over the past decades. Neoadjuvant treatment was used empirically, but evidence was limited due to the lack of high-quality confirmatory studies. Meanwhile, data have become much clearer due to recently published well-conducted randomized controlled trials and meta-analyses. METHODS: Neoadjuvant and perioperative platinum fluoropyrimidine-based combination chemotherapy has now an established role in the treatment of stage II and stage III esophageal adenocarcinoma and cancer of the esophago-gastric junction. Neoadjuvant chemoradiation is now the standard of care for treating stage II and stage III esophageal squamous cell cancer and can also be considered for treating esophageal adenocarcinoma. RESULTS:Patients with esophageal squamous cell cancer treated with definitive chemoradiation achieve comparable long-term survival compared with surgery. Short-term mortality is less with chemoradiation alone, but local tumor control is significantly better with surgery. CONCLUSION: This expert review article outlines current data and literature and delineates recommendable treatment guidelines for localized esophageal cancer.
Authors: Mark van Heijl; Jikke M Omloo; Mark I van Berge Henegouwen; Otto S Hoekstra; Ronald Boellaard; Patrick M Bossuyt; Olivier R Busch; Hugo W Tilanus; Maarten C Hulshof; Ate van der Gaast; Grard A Nieuwenhuijzen; Han J Bonenkamp; John Th Plukker; Miguel A Cuesta; Fiebo J Ten Kate; Jan Pruim; Herman van Dekken; Jacques J Bergman; Gerrit W Sloof; J Jan van Lanschot Journal: Ann Surg Date: 2011-01 Impact factor: 12.969
Authors: Björn L D M Brücher; Karen Becker; Florian Lordick; Ulrich Fink; Mario Sarbia; Hubert Stein; Raymonde Busch; Frank Zimmermann; Michael Molls; Heinz Höfler; Jörg R Siewert Journal: Cancer Date: 2006-05-15 Impact factor: 6.860
Authors: Frederik Hvid-Jensen; Lars Pedersen; Asbjørn Mohr Drewes; Henrik Toft Sørensen; Peter Funch-Jensen Journal: N Engl J Med Date: 2011-10-13 Impact factor: 91.245
Authors: S J Arnott; W Duncan; M Gignoux; H S Hansen; B Launois; K Nygaard; M K B Parmar; A Rousell; G Spilopoulos; G Stewart; J F Tierney; M Wang; Z Rhugang Journal: Cochrane Database Syst Rev Date: 2005-10-19
Authors: F Fiorica; D Di Bona; F Schepis; A Licata; L Shahied; A Venturi; A M Falchi; A Craxì; C Cammà Journal: Gut Date: 2004-07 Impact factor: 23.059
Authors: Sebastian Heinrich; Katrin Janitz; Susanne Merkel; Peter Klein; Joachim Schmidt Journal: Langenbecks Arch Surg Date: 2014-09-21 Impact factor: 3.445
Authors: K Fakhrian; A D Ordu; B Haller; J Theisen; F Lordick; V Bišof; M Molls; H Geinitz Journal: Strahlenther Onkol Date: 2014-04-16 Impact factor: 3.621
Authors: S Sarvepalli; S K Garg; S S Sarvepalli; M P Parikh; V Wadhwa; S Jang; P N Thota; M R Sanaka Journal: Dis Esophagus Date: 2018-09-01 Impact factor: 3.429