Literature DB >> 22969963

Correlation between MTA2 overexpression and tumour progression in esophageal squamous cell carcinoma.

Y P Liu1, B E Shan, X L Wang, L Ma.   

Abstract

The aim of this study was to clarify the clinicopathological outcome and prognostic significance of metastasis-associated gene 2 (MTA2) in esophageal squamous cell carcinoma (ESCC). Immunohistochemical staining for MTA2 was performed on surgical specimens obtained from 162 patients with ESCC. Relationships between MTA2 expression and clinicopathological factors, including prognosis, were analyzed. Significant correlations were noted among MTA2 overexpression and TNM clinical classification staging, depth of invasion, presence of regional lymph node metastasis, presence of distant metastasis, lymphatic invasion, blood-vessel invasion and the 5-year survival rates. The expression of MTA2 protein was correlated with tumour progression. Patients with MTA2 overexpression tended to have poor prognosis compared to patients with MTA2 underexpression.

Entities:  

Year:  2012        PMID： 22969963      PMCID： PMC3438547          DOI： 10.3892/etm.2012.475

Source DB:  PubMed          Journal:  Exp Ther Med        ISSN： 1792-0981            Impact factor:   2.447


  15 in total

Review 1.  Colorectal cancer: a model for epigenetic tumorigenesis.

Authors:  J J L Wong; N J Hawkins; R L Ward
Journal:  Gut       Date:  2006-07-13       Impact factor: 23.059

2.  Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells.

Authors:  Yukun Cui; Airu Niu; Richard Pestell; Rakesh Kumar; Edward M Curran; Yunde Liu; Suzanne A W Fuqua
Journal:  Mol Endocrinol       Date:  2006-04-27

Review 3.  Pemetrexed in the treatment of selected solid tumors.

Authors:  Alex A Adjei
Journal:  Semin Oncol       Date:  2002-04       Impact factor: 4.929

4.  The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.

Authors:  Motoki Saito; Fuyuki Ishikawa
Journal:  J Biol Chem       Date:  2002-07-17       Impact factor: 5.157

5.  Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma.

Authors:  Scott B Shappell; Sandra J Olson; S Erin Hannah; Suzanne Manning; Richard L Roberts; Naoya Masumori; Mitsuo Jisaka; William E Boeglin; Virginia Vader; Dhiren S Dave; M Frances Shook; Tania Z Thomas; Colin D Funk; Alan R Brash; Robert J Matusik
Journal:  Cancer Res       Date:  2003-05-01       Impact factor: 12.701

6.  Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells.

Authors:  Naoyuki Fujita; Masahiro Kajita; Panya Taysavang; Paul A Wade
Journal:  Mol Endocrinol       Date:  2004-09-09

7.  The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.

Authors:  Ya-Li Yao; Wen-Ming Yang
Journal:  J Biol Chem       Date:  2003-08-13       Impact factor: 5.157

Review 8.  Emerging roles of MTA family members in human cancers.

Authors:  Rakesh Kumar; Rui-An Wang; Rozita Bagheri-Yarmand
Journal:  Semin Oncol       Date:  2003-10       Impact factor: 4.929

Review 9.  Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation.

Authors:  Garth L Nicolson; Akihiro Nawa; Yasushi Toh; Shigeki Taniguchi; Katsuhiko Nishimori; Amr Moustafa
Journal:  Clin Exp Metastasis       Date:  2003       Impact factor: 5.150

Review 10.  MTA family of coregulators in nuclear receptor biology and pathology.

Authors:  Bramanandam Manavathi; Kamini Singh; Rakesh Kumar
Journal:  Nucl Recept Signal       Date:  2007-11-30
View more
  5 in total

1.  Melatonin combined with sorafenib synergistically inhibit the invasive ability through targeting metastasis-associated protein 2 expression in human renal cancer cells.

Authors:  Chu-Che Lee; Po-Yu Huang; Yi-Hsien Hsieh; Yong-Syuan Chen; Jen-Pi Tsai
Journal:  Tzu Chi Med J       Date:  2021-10-21

2.  Placental DNA Methylation Related to Both Infant Toenail Mercury and Adverse Neurobehavioral Outcomes.

Authors:  Jennifer Z J Maccani; Devin C Koestler; Barry Lester; E Andrés Houseman; David A Armstrong; Karl T Kelsey; Carmen J Marsit
Journal:  Environ Health Perspect       Date:  2015-03-06       Impact factor: 9.031

3.  Upregulation of metastasis-associated gene 2 promotes cell proliferation and invasion in nasopharyngeal carcinoma.

Authors:  Minhua Wu; Xiaoxia Ye; Xubin Deng; Yanxia Wu; Xiaofang Li; Lin Zhang
Journal:  Onco Targets Ther       Date:  2016-03-18       Impact factor: 4.147

4.  MTA2 as a Potential Biomarker and Its Involvement in Metastatic Progression of Human Renal Cancer by miR-133b Targeting MMP-9.

Authors:  Yong-Syuan Chen; Tung-Wei Hung; Shih-Chi Su; Chia-Liang Lin; Shun-Fa Yang; Chu-Che Lee; Chang-Fang Yeh; Yi-Hsien Hsieh; Jen-Pi Tsai
Journal:  Cancers (Basel)       Date:  2019-11-23       Impact factor: 6.639

5.  miR-1236-3p inhibits invasion and metastasis in gastric cancer by targeting MTA2.

Authors:  Jia-Xiang An; Ming-Hui Ma; Chun-Dong Zhang; Shuai Shao; Nuo-Ming Zhou; Dong-Qiu Dai
Journal:  Cancer Cell Int       Date:  2018-05-01       Impact factor: 5.722
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.