Literature DB >> 22969898

Sequential analysis of diethylnitrosamine-induced hepatocarcinogenesis in rats.

Ryo Abe1, Jun-Ichi Okano, Ryu Imamoto, Yuki Fujise, Yoshikazu Murawaki.   

Abstract

In the present study, we examined the sequential changes of diethylnitrosamine (DEN)-induced hepatocarcinogenesis in Wistar rats. After 14 weeks of DEN treatment, hyperplastic nodules developed as a consequence of the appearance of renewed hepatocytes, degenerated hepatocytes, oval cells and fibrotic changes. Total bilirubin and alanine aminotransferase levels were significantly higher in the DEN group compared to the control group throughout the experimental period. Our data may prove beneficial to future analyses of chemopreventive compounds during various stages of hepatocarcinogenesis in rats.

Entities:  

Year:  2011        PMID： 22969898      PMCID： PMC3438590          DOI： 10.3892/etm.2011.419

Source DB:  PubMed          Journal:  Exp Ther Med        ISSN： 1792-0981            Impact factor:   2.447


  18 in total

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