1-[4-(4-Fluoro-phen-yl)-6-methyl-2-sulfanyl-idene-1,2,3,4-tetra-hydro-pyrimidin-5-yl]ethanone.

In the title mol-ecule, C(13)H(13)FN(2)OS, the heterocyclic ring adopts a slightly distorted flattened boat conformation, and the plane through the four coplanar atoms makes a dihedral angle of 87.45 (14)° with the benzene ring. The thione, acetyl and methyl groups lie on the opposite side of the heterocyclic mean plane to the fluorophenyl group, which has an axial orientation. N-H⋯O, N-H⋯S, C-H⋯F and C-H⋯O inter-molecular hydrogen bonds and a weak C-H⋯π inter-action involving the benzene ring are found in the crystal structure.

Related literature

For chemical and biological applications of dihydro­pyrimidine derivatives and for the closely related crystal structure of the chloro derivative, see: Anuradha et al. (2009 ▶).

Experimental

Crystal data

C13H13FN2OS

M = 264.32

Triclinic,

a = 7.1775 (11) Å

b = 8.1099 (13) Å

c = 12.490 (2) Å

α = 103.529 (15)°

β = 91.933 (14)°

γ = 106.971 (14)°

V = 672.0 (2) Å3

Z = 2

Cu Kα radiation

μ = 2.17 mm−1

T = 123 K

0.59 × 0.36 × 0.06 mm

Data collection

Oxford Diffraction Xcalibur Ruby Gemini diffractometer

Absorption correction: analytical (CrysAlis PRO; Agilent, 2012 ▶) T min = 0.515, T max = 0.891

3949 measured reflections

2629 independent reflections

2109 reflections with I > 2σ(I)

R int = 0.055

Refinement

R[F 2 > 2σ(F 2)] = 0.080

wR(F 2) = 0.233

S = 1.12

2629 reflections

173 parameters

H atoms treated by a mixture of independent and constrained refinement

Δρmax = 0.82 e Å−3

Δρmin = −0.37 e Å−3

Data collection: CrysAlis PRO (Agilent, 2012 ▶); cell refinement: CrysAlis PRO; data reduction: CrysAlis PRO; program(s) used to solve structure: DIRDIF2008 (Beurskens et al., 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: ORTEP-3 (Farrugia, 1997 ▶) and PLATON (Spek, 2009 ▶); software used to prepare material for publication: PLATON.

Crystal structure: contains datablock(s) global, I. DOI: 10.1107/S1600536812033727/wn2486sup1.cif

Structure factors: contains datablock(s) I. DOI: 10.1107/S1600536812033727/wn2486Isup2.hkl

Supplementary material file. DOI: 10.1107/S1600536812033727/wn2486Isup3.cdx

Supplementary material file. DOI: 10.1107/S1600536812033727/wn2486Isup4.cml

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C13H13FN2OS	Z = 2
Mr = 264.32	F(000) = 276
Triclinic, P1	Dx = 1.306 Mg m−3
Hall symbol: -P 1	Melting point: 509 K
a = 7.1775 (11) Å	Cu Kα radiation, λ = 1.54184 Å
b = 8.1099 (13) Å	Cell parameters from 1186 reflections
c = 12.490 (2) Å	θ = 3.7–75.9°
α = 103.529 (15)°	µ = 2.17 mm−1
β = 91.933 (14)°	T = 123 K
γ = 106.971 (14)°	Plate, colourless
V = 672.0 (2) Å3	0.59 × 0.36 × 0.06 mm

Oxford Diffraction Xcalibur Ruby Gemini diffractometer	2629 independent reflections
Radiation source: Enhance (Cu) X-ray Source	2109 reflections with I > 2σ(I)
Graphite monochromator	Rint = 0.055
Detector resolution: 10.5081 pixels mm-1	θmax = 76.1°, θmin = 3.7°
ω scans	h = −7→8
Absorption correction: analytical (CrysAlis PRO; Agilent, 2012)	k = −8→10
Tmin = 0.515, Tmax = 0.891	l = −15→11
3949 measured reflections

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.080	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.233	H atoms treated by a mixture of independent and constrained refinement
S = 1.12	w = 1/[σ2(Fo2) + (0.1003P)2 + 1.2879P] where P = (Fo2 + 2Fc2)/3
2629 reflections	(Δ/σ)max = 0.001
173 parameters	Δρmax = 0.82 e Å−3
0 restraints	Δρmin = −0.37 e Å−3

Geometry. Bond distances, angles etc. have been calculated using the rounded fractional coordinates. All su's are estimated from the variances of the (full) variance-covariance matrix. The cell e.s.d.'s are taken into account in the estimation of distances, angles and torsion angles

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > 2σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
S2	0.18125 (14)	0.34721 (13)	0.46715 (10)	0.0405 (3)
F4	0.7221 (6)	0.3280 (5)	−0.0587 (3)	0.0829 (16)
O15	0.7912 (4)	−0.1016 (4)	0.3039 (3)	0.0520 (12)
N1	0.2057 (5)	0.0276 (4)	0.3682 (3)	0.0387 (10)
N3	0.4983 (5)	0.2512 (4)	0.4147 (3)	0.0349 (10)
C2	0.3046 (5)	0.2035 (5)	0.4140 (3)	0.0351 (11)
C4	0.6032 (5)	0.1414 (5)	0.3474 (3)	0.0344 (11)
C5	0.4912 (5)	−0.0550 (5)	0.3312 (3)	0.0346 (11)
C6	0.2961 (6)	−0.1043 (5)	0.3369 (3)	0.0352 (11)
C15	0.6152 (6)	−0.1729 (5)	0.3037 (4)	0.0394 (14)
C16	0.5357 (6)	−0.3717 (6)	0.2740 (4)	0.0455 (14)
C41	0.6337 (6)	0.1890 (5)	0.2361 (4)	0.0380 (11)
C42	0.4755 (7)	0.1672 (6)	0.1611 (4)	0.0450 (14)
C43	0.5034 (8)	0.2138 (7)	0.0611 (4)	0.0521 (17)
C44	0.6923 (9)	0.2814 (7)	0.0386 (4)	0.0581 (17)
C45	0.8513 (8)	0.3036 (7)	0.1095 (5)	0.0604 (17)
C46	0.8225 (7)	0.2573 (6)	0.2092 (4)	0.0473 (14)
C61	0.1533 (5)	−0.2885 (5)	0.3148 (4)	0.0403 (13)
H1	0.087 (7)	0.005 (6)	0.370 (4)	0.036 (12)*
H3	0.572 (8)	0.356 (8)	0.446 (4)	0.051 (14)*
H4	0.73478	0.16638	0.38822	0.0414*
H16A	0.45343	−0.41343	0.20285	0.0679*
H16B	0.45700	−0.40981	0.33158	0.0679*
H16C	0.64443	−0.42238	0.26819	0.0679*
H42	0.34597	0.11967	0.17837	0.0543*
H43	0.39509	0.19929	0.00998	0.0629*
H45	0.98007	0.35005	0.09089	0.0727*
H46	0.93223	0.27237	0.25940	0.0573*
H61A	0.15509	−0.35405	0.23847	0.0604*
H61B	0.02124	−0.28040	0.32542	0.0604*
H61C	0.19019	−0.35119	0.36620	0.0604*

	U11	U22	U33	U12	U13	U23
S2	0.0293 (5)	0.0314 (5)	0.0635 (7)	0.0129 (4)	0.0089 (4)	0.0121 (4)
F4	0.093 (3)	0.086 (3)	0.062 (2)	0.003 (2)	0.0100 (18)	0.0354 (18)
O15	0.0259 (14)	0.0370 (16)	0.099 (3)	0.0146 (12)	0.0106 (15)	0.0218 (16)
N1	0.0226 (16)	0.0336 (17)	0.061 (2)	0.0104 (13)	0.0064 (14)	0.0118 (15)
N3	0.0276 (16)	0.0267 (16)	0.052 (2)	0.0093 (13)	0.0063 (14)	0.0114 (14)
C2	0.0295 (18)	0.0285 (18)	0.051 (2)	0.0105 (15)	0.0064 (16)	0.0149 (16)
C4	0.0245 (17)	0.0282 (18)	0.053 (2)	0.0101 (14)	0.0051 (15)	0.0127 (16)
C5	0.0275 (18)	0.0242 (17)	0.054 (2)	0.0083 (14)	0.0037 (15)	0.0133 (15)
C6	0.0305 (18)	0.0291 (18)	0.050 (2)	0.0115 (15)	0.0048 (15)	0.0148 (16)
C15	0.0275 (19)	0.040 (2)	0.059 (3)	0.0162 (16)	0.0079 (17)	0.0208 (18)
C16	0.033 (2)	0.038 (2)	0.072 (3)	0.0183 (17)	0.0082 (19)	0.017 (2)
C41	0.037 (2)	0.0273 (18)	0.054 (2)	0.0138 (15)	0.0089 (17)	0.0129 (16)
C42	0.039 (2)	0.043 (2)	0.056 (3)	0.0142 (18)	0.0075 (19)	0.0161 (19)
C43	0.056 (3)	0.049 (3)	0.053 (3)	0.017 (2)	0.000 (2)	0.016 (2)
C44	0.073 (3)	0.051 (3)	0.047 (3)	0.010 (2)	0.011 (2)	0.017 (2)
C45	0.055 (3)	0.059 (3)	0.059 (3)	0.001 (2)	0.015 (2)	0.019 (2)
C46	0.037 (2)	0.046 (2)	0.057 (3)	0.0072 (18)	0.0087 (19)	0.016 (2)
C61	0.0263 (18)	0.0289 (19)	0.067 (3)	0.0078 (15)	0.0098 (17)	0.0148 (18)

S2—C2	1.692 (4)	C41—C42	1.390 (7)
F4—C44	1.360 (6)	C42—C43	1.392 (7)
O15—C15	1.226 (5)	C43—C44	1.372 (9)
N1—C2	1.366 (5)	C44—C45	1.363 (8)
N1—C6	1.395 (5)	C45—C46	1.388 (8)
N3—C2	1.329 (5)	C4—H4	1.0000
N3—C4	1.466 (5)	C16—H16A	0.9800
N1—H1	0.82 (5)	C16—H16B	0.9800
N3—H3	0.85 (6)	C16—H16C	0.9800
C4—C41	1.534 (6)	C42—H42	0.9500
C4—C5	1.522 (6)	C43—H43	0.9500
C5—C6	1.349 (6)	C45—H45	0.9500
C5—C15	1.479 (6)	C46—H46	0.9500
C6—C61	1.501 (6)	C61—H61A	0.9800
C15—C16	1.494 (6)	C61—H61B	0.9800
C41—C46	1.391 (7)	C61—H61C	0.9800
C2—N1—C6	124.1 (4)	C43—C44—C45	122.8 (5)
C2—N3—C4	124.0 (3)	F4—C44—C45	118.6 (6)
C2—N1—H1	113 (3)	C44—C45—C46	119.1 (5)
C6—N1—H1	123 (3)	C41—C46—C45	120.3 (5)
C2—N3—H3	123 (4)	N3—C4—H4	108.00
C4—N3—H3	113 (4)	C5—C4—H4	108.00
S2—C2—N3	123.5 (3)	C41—C4—H4	108.00
N1—C2—N3	116.3 (3)	C15—C16—H16A	110.00
S2—C2—N1	120.3 (3)	C15—C16—H16B	109.00
N3—C4—C5	109.7 (3)	C15—C16—H16C	109.00
N3—C4—C41	110.6 (3)	H16A—C16—H16B	109.00
C5—C4—C41	111.5 (3)	H16A—C16—H16C	109.00
C4—C5—C15	113.3 (3)	H16B—C16—H16C	109.00
C6—C5—C15	127.3 (4)	C41—C42—H42	119.00
C4—C5—C6	119.3 (3)	C43—C42—H42	119.00
N1—C6—C5	118.9 (4)	C42—C43—H43	121.00
N1—C6—C61	112.2 (4)	C44—C43—H43	121.00
C5—C6—C61	128.9 (4)	C44—C45—H45	120.00
C5—C15—C16	123.3 (4)	C46—C45—H45	120.00
O15—C15—C5	117.4 (4)	C41—C46—H46	120.00
O15—C15—C16	119.3 (4)	C45—C46—H46	120.00
C4—C41—C46	120.0 (4)	C6—C61—H61A	109.00
C42—C41—C46	118.8 (4)	C6—C61—H61B	109.00
C4—C41—C42	121.2 (4)	C6—C61—H61C	109.00
C41—C42—C43	121.2 (5)	H61A—C61—H61B	109.00
C42—C43—C44	117.9 (5)	H61A—C61—H61C	110.00
F4—C44—C43	118.6 (5)	H61B—C61—H61C	109.00
C6—N1—C2—S2	−170.5 (3)	C4—C5—C6—C61	174.5 (4)
C6—N1—C2—N3	8.8 (6)	C15—C5—C6—N1	177.7 (4)
C2—N1—C6—C5	−13.1 (6)	C15—C5—C6—C61	−1.6 (7)
C2—N1—C6—C61	166.4 (4)	C4—C5—C15—O15	4.4 (6)
C4—N3—C2—S2	−165.1 (3)	C4—C5—C15—C16	−174.3 (4)
C4—N3—C2—N1	15.6 (5)	C6—C5—C15—O15	−179.3 (4)
C2—N3—C4—C5	−31.5 (5)	C6—C5—C15—C16	1.9 (7)
C2—N3—C4—C41	91.8 (4)	C4—C41—C42—C43	178.7 (4)
N3—C4—C5—C6	25.6 (5)	C46—C41—C42—C43	−0.6 (7)
N3—C4—C5—C15	−157.8 (3)	C4—C41—C46—C45	−178.9 (4)
C41—C4—C5—C6	−97.2 (4)	C42—C41—C46—C45	0.4 (7)
C41—C4—C5—C15	79.4 (4)	C41—C42—C43—C44	0.3 (8)
N3—C4—C41—C42	−61.6 (5)	C42—C43—C44—F4	−179.9 (5)
N3—C4—C41—C46	117.7 (4)	C42—C43—C44—C45	0.2 (8)
C5—C4—C41—C42	60.6 (5)	F4—C44—C45—C46	179.7 (5)
C5—C4—C41—C46	−120.1 (4)	C43—C44—C45—C46	−0.4 (9)
C4—C5—C6—N1	−6.2 (5)	C44—C45—C46—C41	0.1 (8)

D—H···A	D—H	H···A	D···A	D—H···A
N1—H1···O15i	0.82 (5)	2.10 (5)	2.867 (5)	156 (5)
N3—H3···S2ii	0.85 (6)	2.50 (6)	3.350 (4)	174 (6)
C16—H16A···F4iii	0.98	2.50	3.358 (6)	146
C61—H61A···F4iii	0.98	2.47	3.319 (6)	145
C61—H61B···O15i	0.98	2.54	3.383 (5)	144
C16—H16C···Cg2iv	0.98	2.92	3.633 (5)	130

Table 1

Hydrogen-bond geometry (Å, °)

Cg2 is the centroid of the C41–C46 benzene ring.

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N1—H1⋯O15i	0.82 (5)	2.10 (5)	2.867 (5)	156 (5)
N3—H3⋯S2ii	0.85 (6)	2.50 (6)	3.350 (4)	174 (6)
C16—H16A⋯F4iii	0.98	2.50	3.358 (6)	146
C61—H61A⋯F4iii	0.98	2.47	3.319 (6)	145
C61—H61B⋯O15i	0.98	2.54	3.383 (5)	144
C16—H16C⋯Cg2iv	0.98	2.92	3.633 (5)	130

Symmetry codes: (i) ; (ii) ; (iii) ; (iv) .