Literature DB >> 22969221

Early administration of branched-chain amino acid granules.

Toru Ishikawa1.   

Abstract

The effect of malnutrition on survival in patients with decompensated liver cirrhosis has not been well defined. Nutritional intervention with branched-chain amino acid (BCAA) can increase serum albumin concentration in patients with decompensated cirrhosis but its effects on survival are unclear. The BCAA to tyrosine ratio (BTR) is a surrogate marker (the normal range of BTR is between 4.41 and 10.05, and a Fischer's ratio of 1.8 corresponds to a BTR of 3.5) in patients with decompensated liver cirrhosis, and BCAA inhibits hepatic carcinogenesis in patients with compensated cirrhosis. This review discusses data regarding the effect of early administration of BCAA granules based on the ratio of BCAA to BTR on prognosis in patients with cirrhosis.

Entities:  

Keywords:  Albumin; Branched-chain amino acid granules; Branched-chain amino acid to tyrosine ratio; Cancer onset; Liver cirrhosis; Malnutrition; Nutritional intervention; Quality of life

Mesh：

Substances：

Year:  2012        PMID： 22969221      PMCID： PMC3435773          DOI： 10.3748/wjg.v18.i33.4486

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  40 in total

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Journal:  Clin Investig       Date:  1992-06

Review 2.  [Long time oral supplementation with branched-chain amino acids improves survival and decreases recurrences in patients with hepatocellular carcinoma].

Authors:  Kaoru Tsuchiya; Yasuhiro Asahina; Namiki Izumi
Journal:  Nihon Shokakibyo Gakkai Zasshi       Date:  2008-06

3.  Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis.

Authors:  Yasutoshi Muto; Shunichi Sato; Akiharu Watanabe; Hisataka Moriwaki; Kazuyuki Suzuki; Akinobu Kato; Masahiko Kato; Teiji Nakamura; Kiyohiro Higuchi; Shuhei Nishiguchi; Hiromitsu Kumada
Journal:  Clin Gastroenterol Hepatol       Date:  2005-07       Impact factor: 11.382

Review 4.  Branched-chain amino acids as pharmacological nutrients in chronic liver disease.

Authors:  Takumi Kawaguchi; Namiki Izumi; Michael R Charlton; Michio Sata
Journal:  Hepatology       Date:  2011-06-23       Impact factor: 17.425

5.  ESPEN Guidelines on Enteral Nutrition: Liver disease.

Authors:  M Plauth; E Cabré; O Riggio; M Assis-Camilo; M Pirlich; J Kondrup; P Ferenci; E Holm; S Vom Dahl; M J Müller; W Nolte
Journal:  Clin Nutr       Date:  2006-05-16       Impact factor: 7.324

6.  Effects of branched-chain amino acid-enriched nutrient for patients with hepatocellular carcinoma following radiofrequency ablation: a one-year prospective trial.

Authors:  Hidekatsu Kuroda; Akira Ushio; Yasuhiro Miyamoto; Kei Sawara; Kanta Oikawa; Kazuhiro Kasai; Ryujin Endo; Yasuhiro Takikawa; Akinobu Kato; Kazuyuki Suzuki
Journal:  J Gastroenterol Hepatol       Date:  2010-09       Impact factor: 4.029

7.  Oral branched-chain amino acids administration improves impaired liver dysfunction after radiofrequency ablation therapy for hepatocellular carcinoma.

Authors:  Toru Ishikawa; Imai Michitaka; Hiroteru Kamimura; Kazuo Higuchi; Tomoyuki Kubota; Kei-ichi Seki; Hironobu Ohta; Toshiaki Yoshida; Tomoteru Kamimura
Journal:  Hepatogastroenterology       Date:  2009 Sep-Oct

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Authors:  Ranjan Mascarenhas; Sohrab Mobarhan
Journal:  Nutr Rev       Date:  2004-01       Impact factor: 7.110

9.  Determination of branched-chain amino acids and tyrosine in serum of patients with various hepatic diseases, and its clinical usefulness.

Authors:  Y Azuma; M Maekawa; Y Kuwabara; T Nakajima; K Taniguchi; T Kanno
Journal:  Clin Chem       Date:  1989-07       Impact factor: 8.327

10.  Effect of Oral Supplementation with Branched-chain Amino Acid (BCAA) during Radiotherapy in Patients with Hepatocellular Carcinoma: A Double-Blind Randomized Study.

Authors:  Ik Jae Lee; Jinsil Seong; Jung Im Bae; Sei Hwan You; Yumie Rhee; Jong Ho Lee
Journal:  Cancer Res Treat       Date:  2011-03-31       Impact factor: 4.679
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  4 in total

Review 1.  Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseases.

Authors:  Han Ah Lee; Young Chang; Pil Soo Sung; Eileen L Yoon; Hye Won Lee; Jeong-Ju Yoo; Young-Sun Lee; Jihyun An; Do Seon Song; Young Youn Cho; Seung Up Kim; Yoon Jun Kim
Journal:  Clin Mol Hepatol       Date:  2022-07-01

2.  Effect of branched-chain amino acids in patients receiving intervention for hepatocellular carcinoma.

Authors:  Tomoaki Ishihara; Motoh Iwasa; Hideaki Tanaka; Masahiko Kaito; Jiro Ikoma; Toshiya Shibata; Yoshiyuki Takei
Journal:  World J Gastroenterol       Date:  2014-03-14       Impact factor: 5.742

3.  Leucine-rich diet supplementation modulates foetal muscle protein metabolism impaired by Walker-256 tumour.

Authors:  Bread Cruz; Maria C C Gomes-Marcondes
Journal:  Reprod Biol Endocrinol       Date:  2014-01-03       Impact factor: 5.211

4.  Improvement in the Amino Acid Imbalance in Hepatitis C Virus Infected Patients After Viral Eradication by Interferon Treatment.

Authors:  Hirayuki Enomoto; Hiroki Nishikawa; Naoto Ikeda; Nobuhiro Aizawa; Yoshiyuki Sakai; Kazunori Yoh; Ryo Takata; Kunihiro Hasegawa; Chikage Nakano; Takashi Nishimura; Akio Ishii; Tomoyuki Takashima; Yoshinori Iwata; Hiroko Iijima; Shuhei Nishiguchi
Journal:  Hepat Mon       Date:  2016-05-23       Impact factor: 0.660
  4 in total

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