Literature DB >> 22969117

Paracrine signaling between carcinoma cells and mesenchymal stem cells generates cancer stem cell niche via epithelial-mesenchymal transition.

Kati Räsänen1, Meenhard Herlyn.   

Abstract

Li and colleagues present data that cancer cell-derived interleukin-1 induces prostaglandin E(2) and cytokine secretion in mesenchymal stem cells (MSC) to activate β-catenin signaling in the cancer cell. This paracrine signaling between carcinoma cells and MSC leads to the creation of a cancer stem cell niche via epithelial-mesenchymal transition.

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Year:  2012        PMID： 22969117      PMCID： PMC3646332          DOI： 10.1158/2159-8290.CD-12-0312

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  9 in total

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