Literature DB >> 22969115

A genetic snapshot of small cell lung cancer.

Rafael Rosell1, Luciano Wannesson.   

Abstract

Overexpression of PARP1 and enhancer of zeste homolog 2 (EZH2) has been identified in an integrated analysis of multiple proteins involved in intracellular signaling pathways in small cell lung cancer (SCLC) cell lines. The knockdown of PARP1 and EZH2 abrogated SCLC growth. These findings provide the basis for novel predictive markers and new treatment strategies in SCLC, for which there is now a paucity of available therapies.

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Year:  2012        PMID： 22969115     DOI： 10.1158/2159-8290.CD-12-0346

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  6 in total

Review 1.  Chemotherapy advances in small-cell lung cancer.

Authors:  Bryan A Chan; Jermaine I G Coward
Journal:  J Thorac Dis       Date:  2013-10       Impact factor: 2.895

2.  Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small cell lung cancer.

Authors:  Ho-Cheol Kim; Joon Seon Song; Jae Cheol Lee; Dae Ho Lee; Sang-We Kim; Jung-Shin Lee; Woo Sung Kim; Jin Kyung Rho; Sun Ye Kim; Chang-Min Choi
Journal:  Int J Clin Exp Pathol       Date:  2014-09-15

Review 3.  Cellular and molecular biology of small cell lung cancer: an overview.

Authors:  Niki Karachaliou; Sara Pilotto; Chiara Lazzari; Emilio Bria; Filippo de Marinis; Rafael Rosell
Journal:  Transl Lung Cancer Res       Date:  2016-02

Review 4.  Small-cell lung cancer: what we know, what we need to know and the path forward.

Authors:  Adi F Gazdar; Paul A Bunn; John D Minna
Journal:  Nat Rev Cancer       Date:  2017-10-27       Impact factor: 60.716

5.  SOX2 mediates cisplatin resistance in small-cell lung cancer with downregulated expression of hsa-miR-340-5p.

Authors:  Fei Cui; Zhe-Xue Hao; Jin Li; Ya-Lei Zhang; Xu-Kai Li; Jian-Xing He
Journal:  Mol Genet Genomic Med       Date:  2020-03-04       Impact factor: 2.183

6.  Next-generation sequencing reveals frequent consistent genomic alterations in small cell undifferentiated lung cancer.

Authors:  J S Ross; K Wang; O R Elkadi; A Tarasen; L Foulke; C E Sheehan; G A Otto; G Palmer; R Yelensky; D Lipson; J Chmielecki; S M Ali; J Elvin; D Morosini; V A Miller; P J Stephens
Journal:  J Clin Pathol       Date:  2014-09       Impact factor: 3.411
  6 in total

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