Literature DB >> 22967704

DNA methylation inhibitors in cancer: recent and future approaches.

Christina Gros1, Jacques Fahy, Ludovic Halby, Isabelle Dufau, Alexandre Erdmann, Jean-Marc Gregoire, Fréderic Ausseil, Stéphane Vispé, Paola B Arimondo.   

Abstract

This review presents the different human DNA methyltransferases (DNMTs), their biological roles, their mechanisms of action and their role in cancer. The description of assays for detecting DNMT inhibitors (DNMTi) follows. The different known DNMTi are reported along with their advantages, drawbacks and clinical trials. A discussion on the features of the future DNMT inhibitors will conclude this review.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.

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Year:  2012        PMID： 22967704     DOI： 10.1016/j.biochi.2012.07.025

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  60 in total

Review 1.  Predicting response to epigenetic therapy.

Authors:  Marianne B Treppendahl; Lasse S Kristensen; Kirsten Grønbæk
Journal:  J Clin Invest       Date:  2014-01-02       Impact factor: 14.808

2.  Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.

Authors:  Rebecca L Fagan; Diane E Cryderman; Levy Kopelovich; Lori L Wallrath; Charles Brenner
Journal:  J Biol Chem       Date:  2013-07-09       Impact factor: 5.157

Review 3.  Spontaneous regression of neuroblastoma.

Authors:  Garrett M Brodeur
Journal:  Cell Tissue Res       Date:  2018-01-05       Impact factor: 5.249

4.  Aging is associated with hypermethylation of autophagy genes in macrophages.

Authors:  Hany Khalil; Mia Tazi; Kyle Caution; Amr Ahmed; Apurva Kanneganti; Kaivon Assani; Benjamin Kopp; Clay Marsh; Duaa Dakhlallah; Amal O Amer
Journal:  Epigenetics       Date:  2016-02-24       Impact factor: 4.528

Review 5.  The structure, function and evolution of proteins that bind DNA and RNA.

Authors:  William H Hudson; Eric A Ortlund
Journal:  Nat Rev Mol Cell Biol       Date:  2014-10-01       Impact factor: 94.444

Review 6.  Mechanisms of neuroblastoma regression.

Authors:  Garrett M Brodeur; Rochelle Bagatell
Journal:  Nat Rev Clin Oncol       Date:  2014-10-21       Impact factor: 66.675

7.  Human DNMT1 transition state structure.

Authors:  Quan Du; Zhen Wang; Vern L Schramm
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-29       Impact factor: 11.205

8.  Facile synthesis of SAM-peptide conjugates through alkyl linkers targeting protein N-terminal methyltransferase 1.

Authors:  Gang Zhang; Rong Huang
Journal:  RSC Adv       Date:  2016-01-11       Impact factor: 3.361

Review 9.  Epigenetic effects of green tea polyphenols in cancer.

Authors:  Susanne M Henning; Piwen Wang; Catherine L Carpenter; David Heber
Journal:  Epigenomics       Date:  2013-12       Impact factor: 4.778

10.  Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth.

Authors:  Rajneesh Pathania; Sabarish Ramachandran; Gurusamy Mariappan; Priyanka Thakur; Huidong Shi; Jeong-Hyeon Choi; Santhakumar Manicassamy; Ravindra Kolhe; Puttur D Prasad; Suash Sharma; Bal L Lokeshwar; Vadivel Ganapathy; Muthusamy Thangaraju
Journal:  Cancer Res       Date:  2016-04-05       Impact factor: 12.701
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