Literature DB >> 22966964

Iron-catalyzed cross-coupling of N-heterocyclic chlorides and bromides with arylmagnesium reagents.

Olesya M Kuzmina1, Andreas K Steib, Dietmar Flubacher, Paul Knochel.   

Abstract

A simple, practical iron salt catalyzed procedure allows fast cross-couplings of N-heterocyclic chlorides and bromides with various electron-rich and -poor arylmagnesium reagents. A solvent mixture of THF and tBuOMe is found to be essential for achieving high yields mainly by avoiding homocoupling side reactions.

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Year:  2012        PMID： 22966964     DOI： 10.1021/ol302136c

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides.

Authors:  Oleg V Larionov; David Stephens; Adelphe Mfuh; Gabriel Chavez
Journal:  Org Lett       Date:  2014-01-10       Impact factor: 6.005

2.  Isolation and characterization of a tetramethyliron(III) ferrate: an intermediate in the reduction pathway of ferric salts with MeMgBr.

Authors:  Malik H Al-Afyouni; Kathlyn L Fillman; William W Brennessel; Michael L Neidig
Journal:  J Am Chem Soc       Date:  2014-10-28       Impact factor: 15.419

3.  Iron(II) Active Species in Iron-Bisphosphine Catalyzed Kumada and Suzuki-Miyaura Cross-Couplings of Phenyl Nucleophiles and Secondary Alkyl Halides.

Authors:  Stephanie L Daifuku; Jared L Kneebone; Benjamin E R Snyder; Michael L Neidig
Journal:  J Am Chem Soc       Date:  2015-08-26       Impact factor: 15.419
  3 in total

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