Literature DB >> 2296631

Pirenperone does not attenuate morphine analgesia in spinal rats.

D Paul1, J P Pinel.   

Abstract

The selective serotonin type-2 (S2) receptor blocker pirenperone (0.24 mg/kg, SC) attenuates morphine-produced tail-flick antinociception in intact rats, but not in rats with transected spinal cords. These results suggest that S2 receptor blockade does not affect intraspinal opioid antinociception. Together with evidence that there are virtually no S2 receptors in the dorsal spinal cord, supraspinal S2 receptors are implicated in the mediation of morphine-produced antinociception.

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Year:  1990        PMID： 2296631     DOI： 10.1007/bf02245797

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  29 in total

1.  Two populations of spinothalamic tract neurons with opposite responses to 5-hydroxytryptamine.

Authors:  L M Jordan; D R Kenshalo; R F Martin; L H Haber; W D Willis
Journal:  Brain Res       Date:  1979-03-23       Impact factor: 3.252

2.  Antagonism by methysergide and cinanserin of the antinociceptive action of morphine administered into the periaqueductal gray.

Authors:  T L Yaksh; J C DuChateau; T A Rudy
Journal:  Brain Res       Date:  1976-03-12       Impact factor: 3.252

Review 3.  Brainstem control of spinal pain-transmission neurons.

Authors:  H L Fields; A I Basbaum
Journal:  Annu Rev Physiol       Date:  1978       Impact factor: 19.318

Review 4.  Pharmacology of putative neurotransmitters and receptors: 5-hydroxytryptamine.

Authors:  M H Roberts
Journal:  Prog Brain Res       Date:  1988       Impact factor: 2.453

5.  Computer-assisted autoradiographic localization of subtypes of serotonin1 receptors in rat brain.

Authors:  P P Deshmukh; H I Yamamura; L Woods; D L Nelson
Journal:  Brain Res       Date:  1983-12-12       Impact factor: 3.252

6.  Separate involvement of the spinal noradrenergic and serotonergic systems in morphine analgesia: the differences in mechanical and thermal algesic tests.

Authors:  Y Kuraishi; Y Harada; S Aratani; M Satoh; H Takagi
Journal:  Brain Res       Date:  1983-08-29       Impact factor: 3.252

7.  In vivo binding of [3H]ketanserin on serotonin S2-receptors in rat brain.

Authors:  P M Laduron; P F Janssen; J E Leysen
Journal:  Eur J Pharmacol       Date:  1982-06-16       Impact factor: 4.432

Review 8.  5-Hydroxytryptamine and antinociception.

Authors:  M H Roberts
Journal:  Neuropharmacology       Date:  1984-12       Impact factor: 5.250

9.  Attenuation of morphine-induced analgesia by p-chlorophenylalanine and p-chloroamphetamine: test-dependent effects and evidence for brainstem 5-hydroxytryptamine involvement.

Authors:  O G Berge; K Hole; S O Ogren
Journal:  Brain Res       Date:  1983-07-18       Impact factor: 3.252

10.  Attenuation of morphine analgesia by the S2 antagonists, pirenperone and ketanserin.

Authors:  D Paul; M J Mana; J G Pfaus; J P Pinel
Journal:  Pharmacol Biochem Behav       Date:  1988-11       Impact factor: 3.533
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