OBJECTIVES: To identify associated factors and influence on long-term outcome of heavy alcohol intake in a large prospective cohort of consecutive patients with a spontaneous intracerebral hemorrhage (ICH). METHODS: Between November 2004 and March 2009, we prospectively recruited 562 consecutive adults with a spontaneous ICH. We excluded patients without information on drinking habit (n = 22). Heavy alcohol intake was defined as a regular consumption of more than 300 g alcohol/week. We performed bivariate and multivariate analyses (logistic regression) based on demographic and radiologic models. Survival analyses were performed using Kaplan-Meier statistics. RESULTS: Among 540 patients with ICH, 137 (25) were heavy alcohol drinkers (median age 60 vs 74 years in nonabusers; p < 0.0001). In the multivariate demographic model, heavy alcohol drinkers were less likely to be older (odds ratio [OR] 0.97 per 1-year increase, 95% confidence interval [CI] 0.95-0.98) and to have a history of ischemic heart disease (OR 0.34, 95% CI 0.15-0.77) and more likely to be smokers (OR 3.96, 95% CI 2.43-6.46). In the radiologic model, independent factors were nonlobar location of ICH (OR 1.71, 95% CI 1.05-2.77) and less severe leukoaraiosis (OR 0.76 per 1-step increase, 95%CI 0.62-0.73). Platelet counts and prothrombin ratio were significantly lower among heavy alcohol drinkers (respectively, p = 0.01 and p = 0.017). Heavy alcohol intake was predictive of 2 years mortality only among patients younger than 60 years with nonlobar ICH (hazard ratio 1.96, 95% CI 1.06-3.63). CONCLUSION: Heavy alcohol intake is associated with the occurrence of ICH at a young age. However, the underlying vasculopathy remains unexplored in these patients. Indirect markers suggest small-vessel disease at an early stage that might be enhanced by moderate hemostatic disorders.
OBJECTIVES: To identify associated factors and influence on long-term outcome of heavy alcohol intake in a large prospective cohort of consecutive patients with a spontaneous intracerebral hemorrhage (ICH). METHODS: Between November 2004 and March 2009, we prospectively recruited 562 consecutive adults with a spontaneous ICH. We excluded patients without information on drinking habit (n = 22). Heavy alcohol intake was defined as a regular consumption of more than 300 g alcohol/week. We performed bivariate and multivariate analyses (logistic regression) based on demographic and radiologic models. Survival analyses were performed using Kaplan-Meier statistics. RESULTS: Among 540 patients with ICH, 137 (25) were heavy alcohol drinkers (median age 60 vs 74 years in nonabusers; p < 0.0001). In the multivariate demographic model, heavy alcohol drinkers were less likely to be older (odds ratio [OR] 0.97 per 1-year increase, 95% confidence interval [CI] 0.95-0.98) and to have a history of ischemic heart disease (OR 0.34, 95% CI 0.15-0.77) and more likely to be smokers (OR 3.96, 95% CI 2.43-6.46). In the radiologic model, independent factors were nonlobar location of ICH (OR 1.71, 95% CI 1.05-2.77) and less severe leukoaraiosis (OR 0.76 per 1-step increase, 95%CI 0.62-0.73). Platelet counts and prothrombin ratio were significantly lower among heavy alcohol drinkers (respectively, p = 0.01 and p = 0.017). Heavy alcohol intake was predictive of 2 years mortality only among patients younger than 60 years with nonlobar ICH (hazard ratio 1.96, 95% CI 1.06-3.63). CONCLUSION: Heavy alcohol intake is associated with the occurrence of ICH at a young age. However, the underlying vasculopathy remains unexplored in these patients. Indirect markers suggest small-vessel disease at an early stage that might be enhanced by moderate hemostatic disorders.
Authors: James F Meschia; Cheryl Bushnell; Bernadette Boden-Albala; Lynne T Braun; Dawn M Bravata; Seemant Chaturvedi; Mark A Creager; Robert H Eckel; Mitchell S V Elkind; Myriam Fornage; Larry B Goldstein; Steven M Greenberg; Susanna E Horvath; Costantino Iadecola; Edward C Jauch; Wesley S Moore; John A Wilson Journal: Stroke Date: 2014-10-28 Impact factor: 7.914
Authors: Jamie I Verhoeven; Marco Pasi; Barbara Casolla; Hilde Hénon; Frank-Erik de Leeuw; Didier Leys; Catharina Jm Klijn; Charlotte Cordonnier Journal: Eur Stroke J Date: 2021-06-18
Authors: Carey Camille Roberts; George J Snipes; Jong Mi Ko; William Clifford Roberts; Joseph M Guileyardo Journal: Proc (Bayl Univ Med Cent) Date: 2014-10
Authors: Ching-Jen Chen; W Mark Brown; Charles J Moomaw; Carl D Langefeld; Jennifer Osborne; Bradford B Worrall; Daniel Woo; Sebastian Koch Journal: Neurology Date: 2017-04-26 Impact factor: 9.910
Authors: Charlotte J J van Asch; Birgitta K Velthuis; Gabriël J E Rinkel; Ale Algra; Gérard A P de Kort; Theo D Witkamp; Johanna C M de Ridder; Koen M van Nieuwenhuizen; Frank-Erik de Leeuw; Wouter J Schonewille; Paul L M de Kort; Diederik W Dippel; Theodora W M Raaymakers; Jeannette Hofmeijer; Marieke J H Wermer; Henk Kerkhoff; Korné Jellema; Irene M Bronner; Michel J M Remmers; Henri Paul Bienfait; Ron J G M Witjes; Jacoba P Greving; Catharina J M Klijn Journal: BMJ Date: 2015-11-09