AIM OF THE REVIEW: To study the prevalence of drug interactions in hospital healthcare by reviewing literature. METHOD: A review was carried out of studies written in Spanish and English on the prevalence of drug interactions in hospital care published in Pubmed between January 1990 and September 2008. The search strategy combined free text and MeSH terms, using the following keywords: "Drug interaction", "prevalence" and "hospital". For each article, we classified independent variables (pathology, age of population, whether patients were hospitalized or not, geographical location, etc.) and dependent variables (number of interactions per 100 patients studied, prevalence of patients with interactions, most common drug interactions, and others). RESULTS: The search generated 436 articles. Finally, 47 articles were selected for the study, 3 provided results about drug interactions with real clinical consequences, 42 about potential interactions, and 2 described both. The prevalence of patients with interactions was between 15 and 45 % and the number of interactions per 100 patients was between 37 and 106, depending on the group of studies analyzed. There was a considerable increase in these rates in patients with heart diseases and elderly persons. CONCLUSION: There is a large number of studies on the prevalence of drug interactions in hospitals but they report widely varying results. The prevalence is higher in patients with heart diseases and elderly people.
AIM OF THE REVIEW: To study the prevalence of drug interactions in hospital healthcare by reviewing literature. METHOD: A review was carried out of studies written in Spanish and English on the prevalence of drug interactions in hospital care published in Pubmed between January 1990 and September 2008. The search strategy combined free text and MeSH terms, using the following keywords: "Drug interaction", "prevalence" and "hospital". For each article, we classified independent variables (pathology, age of population, whether patients were hospitalized or not, geographical location, etc.) and dependent variables (number of interactions per 100 patients studied, prevalence of patients with interactions, most common drug interactions, and others). RESULTS: The search generated 436 articles. Finally, 47 articles were selected for the study, 3 provided results about drug interactions with real clinical consequences, 42 about potential interactions, and 2 described both. The prevalence of patients with interactions was between 15 and 45 % and the number of interactions per 100 patients was between 37 and 106, depending on the group of studies analyzed. There was a considerable increase in these rates in patients with heart diseases and elderly persons. CONCLUSION: There is a large number of studies on the prevalence of drug interactions in hospitals but they report widely varying results. The prevalence is higher in patients with heart diseases and elderly people.
Authors: R Raschetti; M Morgutti; F Menniti-Ippolito; A Belisari; A Rossignoli; P Longhini; C La Guidara Journal: Eur J Clin Pharmacol Date: 1999-02 Impact factor: 2.953
Authors: Alfredo Jose Pardo-Cabello; Victoria Manzano-Gamero; Esperanza Del Pozo; Francisco Javier Gómez Jiménez; Juan de Dios Luna; Emilio Puche Cañas Journal: Intern Emerg Med Date: 2018-10-24 Impact factor: 3.397
Authors: Stephan Pflugbeil; Karin Böckl; Reinhold Pongratz; Marianne Leitner; Winfried Graninger; Astrid Ortner Journal: Rheumatol Int Date: 2020-02-12 Impact factor: 2.631