Literature DB >> 22965071

CD40-CD40L: linking pancreatic, adipose tissue and vascular inflammation in type 2 diabetes and its complications.

Tom Seijkens1, Pascal Kusters, David Engel, Esther Lutgens.   

Abstract

Numerous epidemiological studies have consistently demonstrated the strong association between type 2 diabetes mellitus (T2DM) and an increased risk to develop cardiovascular disease. The pathogenesis of T2DM and its complications are characterized by pancreatic, adipose tissue and vascular inflammation. CD40 and CD40L, members of the tumour necrosis factor (receptor) TNF(R) family, are well known for their role in immunity and inflammation. Here we give an overview on the role of CD40-CD40L interactions in the pathogenesis of T2DM with a special focus on pancreatic, adipose tissue and vascular inflammation. In addition, we explore the role of soluble CD40L (sCD40L) as a potential biomarker for the development of cardiovascular disease in T2DM subjects. Finally, the therapeutic potential of CD40-CD40L inhibition in T2DM is highlighted.

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Year:  2012        PMID： 22965071     DOI： 10.1177/1479164112455817

Source DB:  PubMed          Journal:  Diab Vasc Dis Res        ISSN： 1479-1641            Impact factor:   3.291


  18 in total

1.  Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice.

Authors:  S M van den Berg; T T P Seijkens; P J H Kusters; B Zarzycka; L Beckers; M den Toom; M J J Gijbels; A Chatzigeorgiou; C Weber; M P J de Winther; T Chavakis; G A F Nicolaes; E Lutgens
Journal:  Int J Obes (Lond)       Date:  2014-11-13       Impact factor: 5.095

2.  The expression of inflammatory cytokines on the aorta endothelia are up-regulated in pinealectomized rats.

Authors:  Yu Wang; Xiaoyan Liu; Wei Wang; Wei Song; Lianfeng Chen; Quan Fang; Xiaowei Yan
Journal:  Inflammation       Date:  2013-12       Impact factor: 4.092

Review 3.  Lymphocyte roles in metabolic dysfunction: of men and mice.

Authors:  Blanche C Ip; Andrew E Hogan; Barbara S Nikolajczyk
Journal:  Trends Endocrinol Metab       Date:  2015-01-05       Impact factor: 12.015

4.  High plasma CD40 ligand level is associated with more advanced stages and worse prognosis in colorectal cancer.

Authors:  Zoltan Herold; Magdolna Herold; Gyorgy Herczeg; Agnes Fodor; Attila Marcell Szasz; Magdolna Dank; Aniko Somogyi
Journal:  World J Clin Cases       Date:  2022-05-06       Impact factor: 1.534

5.  Temporal response characterization across individual multiomics profiles of prediabetic and diabetic subjects.

Authors:  Minzhang Zheng; Carlo Piermarocchi; George I Mias
Journal:  Sci Rep       Date:  2022-07-15       Impact factor: 4.996

6.  Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters.

Authors:  T H Tu; C-S Kim; J-H Kang; I S Nam-Goong; C W Nam; E S Kim; Y I Kim; J I Choi; T Kawada; T Goto; T Park; J H Yoon Park; M-S Choi; R Yu
Journal:  Int J Obes (Lond)       Date:  2013-11-27       Impact factor: 5.095

7.  CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance.

Authors:  Chang-An Guo; Sophia Kogan; Shinya U Amano; Mengxi Wang; Sezin Dagdeviren; Randall H Friedline; Myriam Aouadi; Jason K Kim; Michael P Czech
Journal:  Am J Physiol Endocrinol Metab       Date:  2013-03-12       Impact factor: 4.310

8.  Effect of Danhong Injection Combined with Naoxintong Tablets on Prognosis and Inflammatory Factor Expression in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention.

Authors:  Yun Lv; Yaping Pan; Yan Gao; Jingqian Lu; Yi Li; Jie Bai; Jing Zhai
Journal:  Acta Cardiol Sin       Date:  2015-07       Impact factor: 2.672

9.  HMGB1 is activated in type 2 diabetes mellitus patients and in mesangial cells in response to high glucose.

Authors:  Yan Chen; Fengli Qiao; Ying Zhao; Yanjun Wang; Guifeng Liu
Journal:  Int J Clin Exp Pathol       Date:  2015-06-01

10.  PPARγ ligands decrease hydrostatic pressure-induced platelet aggregation and proinflammatory activity.

Authors:  Fang Rao; Ren-Qiang Yang; Xiao-Shu Chen; Jin-Song Xu; Hui-Min Fu; Hai Su; Ling Wang
Journal:  PLoS One       Date:  2014-02-28       Impact factor: 3.240
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