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Literature DB >> 2296458

Transforming growth factor-beta in the regulation of fracture repair.

Abstract

The complexity of the fracture repair process has been apparent to both clinicians and scientists since its first histologic description. How fracture repair is regulated, however, remains unclear. Transforming growth factor-beta (TGF-beta), one member of a class of proteins known as growth factors, may be involved in the formation of bone and cartilage. Our experimental findings implicate TGF-beta as an important regulator of cell proliferation, differentiation, and synthesis of extracellular matrix. Further elucidation of how TGF-beta regulates bone physiology is necessary to improve therapy in pathologic conditions.

Entities: Disease Gene

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Year: 1990 PMID： 2296458

Source DB: PubMed Journal: Orthop Clin North Am ISSN： 0030-5898 Impact factor: 2.472

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Cited

25 in total

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Authors: Molly M Stevens; Robert P Marini; Dirk Schaefer; Joshua Aronson; Robert Langer; V Prasad Shastri
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3. Physiology of bone turnover and its application in contemporary maxillofacial surgery. A review.

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4. The effect of Astragalus extractive on alveolar bone rebuilding progress of tooth extracted socket of ovariectomied rats.

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Review 5. Physical activity in the prevention and amelioration of osteoporosis in women : interaction of mechanical, hormonal and dietary factors.

Authors: Katarina T Borer
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6. Systemic administration of transforming growth factor-beta 2 prevents the impaired bone formation and osteopenia induced by unloading in rats.

Authors: M Machwate; E Zerath; X Holy; M Hott; D Godet; A Lomri; P J Marie
Journal: J Clin Invest Date: 1995-09 Impact factor: 14.808

Transforming growth factor-beta in the regulation of fracture repair.

1. Craniofacial Bone Grafting: Wolff's Law Revisited.

2. In vivo engineering of organs: the bone bioreactor.

3. Physiology of bone turnover and its application in contemporary maxillofacial surgery. A review.

4. The effect of Astragalus extractive on alveolar bone rebuilding progress of tooth extracted socket of ovariectomied rats.

Review 5. Physical activity in the prevention and amelioration of osteoporosis in women : interaction of mechanical, hormonal and dietary factors.

6. Systemic administration of transforming growth factor-beta 2 prevents the impaired bone formation and osteopenia induced by unloading in rats.

Review 7. Ankylosing spondylitis, IgA, and transforming growth factors.

8. Insulinlike growth factor gene expression in human fracture callus.

9. Transforming growth factor beta 1-induced cellular heterogeneity in the periosteum of rat parietal bones.

10. TGF-β1 as possible link between loss of bone mineral density and chronic inflammation.