Literature DB >> 22961974

Bacteria-responsive multifunctional nanogel for targeted antibiotic delivery.

Meng-Hua Xiong1, Ya-Juan Li, Yan Bao, Xian-Zhu Yang, Bing Hu, Jun Wang.   

Abstract

Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger antibiotic release by degrading the polyphosphoester core. The mannosylated nanogel preferentially delivers drugs to macrophages and leads to drug accumulation at bacterial infection sites through macrophage transport. This nanogel provides macrophage targeting and lesion site-activatable drug release properties, which enhances bacterial growth inhibition.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22961974     DOI： 10.1002/adma.201202847

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  38 in total

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