Literature DB >> 22961651

The α-ketoglutarate/Fe(II)-dependent dioxygenase VldW is responsible for the formation of validamycin B.

Khaled H Almabruk1, Shumpei Asamizu, Ada Chang, Sheril G Varghese, Taifo Mahmud.   

Abstract

From A to B: Through detailed biochemical investigations, we discovered that VldW, an α-ketoglutarate/Fe(II)-dependent dioxygenase, regioselectively hydroxylates validamycin A to validamycin B. The results provide insights into the biosynthesis of hydroxylated validamycins and could be used to control the metabolic outcomes of the validamycin pathway.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22961651      PMCID： PMC3517013          DOI： 10.1002/cbic.201200464

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  16 in total

1.  VioC is a non-heme iron, alpha-ketoglutarate-dependent oxygenase that catalyzes the formation of 3S-hydroxy-L-arginine during viomycin biosynthesis.

Authors:  Xihou Yin; T Mark Zabriskie
Journal:  Chembiochem       Date:  2004-09-06       Impact factor: 3.164

2.  Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704).

Authors:  Deepak Singh; Myung-Ji Seo; Hyung-Jin Kwon; Arishma Rajkarnikar; Kyoung-Rok Kim; Soon-Ok Kim; Joo-Won Suh
Journal:  Gene       Date:  2006-04-05       Impact factor: 3.688

Review 3.  Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds.

Authors:  Patricia M Flatt; Taifo Mahmud
Journal:  Nat Prod Rep       Date:  2006-12-21       Impact factor: 13.423

4.  Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.

Authors:  Shumpei Asamizu; Jongtae Yang; Khaled H Almabruk; Taifo Mahmud
Journal:  J Am Chem Soc       Date:  2011-07-18       Impact factor: 15.419

5.  Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin.

Authors:  Miriam Bredebach; Ulrich Matern; Stefan Martens
Journal:  Phytochemistry       Date:  2011-02-24       Impact factor: 4.072

6.  Biosynthesis of the validamycins: identification of intermediates in the biosynthesis of validamycin A by Streptomyces hygroscopicus var. limoneus.

Authors:  H Dong; T Mahmud; I Tornus; S Lee; H G Floss
Journal:  J Am Chem Soc       Date:  2001-03-28       Impact factor: 15.419

7.  Validamycin G and validoxylamine G, new members of the validamycins.

Authors:  Y Kameda; N Asano; T Yamaguchi; K Matsui; S Horii; H Fukase
Journal:  J Antibiot (Tokyo)       Date:  1986-10       Impact factor: 2.649

8.  Studies on validamycins, new antibiotics. I. Streptomyces hygroscopicus var. limoneus nov. var., validamycin-producing organism.

Authors:  T Iwasa; H Yamamoto; M Shibata
Journal:  J Antibiot (Tokyo)       Date:  1970-12       Impact factor: 2.649

9.  Effect of validamycins on glycohydrolases of Rhizoctonia solani.

Authors:  N Asano; T Yamaguchi; Y Kameda; K Matsui
Journal:  J Antibiot (Tokyo)       Date:  1987-04       Impact factor: 2.649

10.  Conversion of (2S)-arginine to (2S,3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861.

Authors:  Jianhua Ju; Sarah G Ozanick; Ben Shen; Michael G Thomas
Journal:  Chembiochem       Date:  2004-09-06       Impact factor: 3.164
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  1 in total

1.  A study on the structure, mechanism, and biochemistry of kanamycin B dioxygenase (KanJ)-an enzyme with a broad range of substrates.

Authors:  Beata Mrugała; Anna Miłaczewska; Przemyslaw Jerzy Porebski; Ewa Niedzialkowska; Maciej Guzik; Wladek Minor; Tomasz Borowski
Journal:  FEBS J       Date:  2020-07-27       Impact factor: 5.542
  1 in total

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