Literature DB >> 2296008

Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases.

M R Angelastro1, S Mehdi, J P Burkhart, N P Peet, P Bey.   

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Year:  1990        PMID： 2296008     DOI： 10.1021/jm00163a002

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  11 in total

1.  Delineation of a fundamental alpha-ketoheterocycle substituent effect for use in the design of enzyme inhibitors.

Authors:  F Anthony Romero; Inkyu Hwang; Dale L Boger
Journal:  J Am Chem Soc       Date:  2006-11-01       Impact factor: 15.419

Review 2.  Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death.

Authors:  N A Thornberry; S M Molineaux
Journal:  Protein Sci       Date:  1995-01       Impact factor: 6.725

3.  Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors.

Authors:  Asli Ovat; Zhao Zhao Li; Christina Y Hampton; Seneshaw A Asress; Facundo M Fernández; Jonathan D Glass; James C Powers
Journal:  J Med Chem       Date:  2010-09-09       Impact factor: 7.446

4.  Identification and optimization of a novel inhibitor of mitochondrial calpain 10.

Authors:  Kyle A Rasbach; David D Arrington; Sina Odejinmi; Chris Giguere; Craig C Beeson; Rick G Schnellmann
Journal:  J Med Chem       Date:  2009-01-08       Impact factor: 7.446

5.  Synthesis of alpha-keto-imides via oxidation of ynamides.

Authors:  Ziyad F Al-Rashid; Whitney L Johnson; Richard P Hsung; Yonggang Wei; Pei-Yuan Yao; Renhei Liu; Kang Zhao
Journal:  J Org Chem       Date:  2008-10-21       Impact factor: 4.354

6.  Affinity labelling of the Ca(2+)-activated neutral proteinase (calpain) in intact human platelets.

Authors:  J Anagli; J Hagmann; E Shaw
Journal:  Biochem J       Date:  1993-01-01       Impact factor: 3.857

7.  Inhibitors of human heart chymase based on a peptide library.

Authors:  M Bastos; N J Maeji; R H Abeles
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-18       Impact factor: 11.205

8.  A Diverse Library of Chiral Cyclopropane Scaffolds via Chemoenzymatic Assembly and Diversification of Cyclopropyl Ketones.

Authors:  Donggeon Nam; Viktoria Steck; Robert J Potenzino; Rudi Fasan
Journal:  J Am Chem Soc       Date:  2021-01-26       Impact factor: 15.419

Review 9.  Why calpain inhibitors are interesting leading compounds to search for new therapeutic options to treat leishmaniasis?

Authors:  Vitor Ennes-Vidal; Rubem Figueiredo Sadock Menna-Barreto; Marta Helena Branquinha; André Luis Souza Dos Santos; Claudia Masini D'Avila-Levy
Journal:  Parasitology       Date:  2016-11-21       Impact factor: 3.234

10.  2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2.

Authors:  Maroula G Kokotou; Gerasimia Galiatsatou; Victoria Magrioti; Giorgos Koutoulogenis; Efrosini Barbayianni; Dimitris Limnios; Varnavas D Mouchlis; Banita Satpathy; Aaron Navratil; Edward A Dennis; George Kokotos
Journal:  Sci Rep       Date:  2017-08-01       Impact factor: 4.379
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