Literature DB >> 22958927

Relief with rapamycin: mTOR inhibition protects against radiation-induced mucositis.

Toren Finkel1.   

Abstract

In this issue of Cell Stem Cell, Iglesias-Bartolome et al. (2012) show that mTOR inhibition with rapamycin protects against mucositis in mice, suggesting potential treatment strategies against this harmful side effect of anticancer therapies. In normal tissues, rapamycin prevents epithelial stem cell senescence by reducing oxidative stress through increased MnSOD.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22958927      PMCID： PMC3466808          DOI： 10.1016/j.stem.2012.08.003

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  7 in total

Review 1.  mTOR signaling in growth control and disease.

Authors:  Mathieu Laplante; David M Sabatini
Journal:  Cell       Date:  2012-04-13       Impact factor: 41.582

2.  Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.

Authors:  Derrick J Rossi; David Bryder; Jun Seita; Andre Nussenzweig; Jan Hoeijmakers; Irving L Weissman
Journal:  Nature       Date:  2007-06-07       Impact factor: 49.962

Review 3.  Oral mucositis.

Authors:  Stephen T Sonis
Journal:  Anticancer Drugs       Date:  2011-08       Impact factor: 2.248

4.  mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

Authors:  Rogerio M Castilho; Cristiane H Squarize; Lewis A Chodosh; Bart O Williams; J Silvio Gutkind
Journal:  Cell Stem Cell       Date:  2009-09-04       Impact factor: 24.633

5.  A deletion polymorphism in glutathione-S-transferase mu (GSTM1) and/or theta (GSTT1) is associated with an increased risk of toxicity after autologous blood and marrow transplantation.

Authors:  Theresa Hahn; Eugenia Zhelnova; Lara Sucheston; Irina Demidova; Valery Savchenko; Minoo Battiwalla; Shannon L Smiley; Christine B Ambrosone; Philip L McCarthy
Journal:  Biol Blood Marrow Transplant       Date:  2010-01-13       Impact factor: 5.742

6.  Augmented Wnt signaling in a mammalian model of accelerated aging.

Authors:  Hongjun Liu; Maria M Fergusson; Rogerio M Castilho; Jie Liu; Liu Cao; Jichun Chen; Daniela Malide; Ilsa I Rovira; Daniel Schimel; Calvin J Kuo; J Silvio Gutkind; Paul M Hwang; Toren Finkel
Journal:  Science       Date:  2007-08-10       Impact factor: 47.728

7.  TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species.

Authors:  Chong Chen; Yu Liu; Runhua Liu; Tsuneo Ikenoue; Kun-Liang Guan; Yang Liu; Pan Zheng
Journal:  J Exp Med       Date:  2008-09-22       Impact factor: 14.307
  7 in total
  2 in total

1.  mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a.

Authors:  Ajuan Chen; Jian Jin; Shasha Cheng; Zezheng Liu; Cheng Yang; Qingjing Chen; Wenquan Liang; Kai Li; Dawei Kang; Zhicong Ouyang; Chenfeng Yao; Xiaochun Bai; Qingchu Li; Dadi Jin; Bin Huang
Journal:  Bone Res       Date:  2022-03-08       Impact factor: 13.567

2.  Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway.

Authors:  Dan He; Hongguang Wu; Jinnan Xiang; Xinsen Ruan; Peike Peng; Yuanyuan Ruan; Ye-Guang Chen; Yibin Wang; Qiang Yu; Hongbing Zhang; Samy L Habib; Ronald A De Pinho; Huijuan Liu; Baojie Li
Journal:  Nat Commun       Date:  2020-01-02       Impact factor: 14.919
  2 in total

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