Literature DB >> 22958921

βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism.

Xunshan Ding1, Jamie Boney-Montoya, Bryn M Owen, Angie L Bookout, Katie Colbert Coate, David J Mangelsdorf, Steven A Kliewer.   

Abstract

Fibroblast growth factor 21 (FGF21) is a fasting-induced hepatokine that has potent pharmacologic effects in mice, which include improving insulin sensitivity and blunting growth. The single-transmembrane protein βKlotho functions as a coreceptor for FGF21 in vitro. To determine if βKlotho is required for FGF21 action in vivo, we generated whole-body and adipose tissue-selective βKlotho-knockout mice. All of the effects of FGF21 on growth and metabolism were lost in whole-body βKlotho-knockout mice. Selective elimination of βKlotho in adipose tissue blocked the acute insulin-sensitizing effects of FGF21. Taken together, these data demonstrate that βKlotho is essential for FGF21 activity and that βKlotho in adipose tissue contributes to the beneficial metabolic actions of FGF21.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22958921      PMCID： PMC3447537          DOI： 10.1016/j.cmet.2012.08.002

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  34 in total

1.  Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function.

Authors:  M D Tallquist; P Soriano
Journal:  Genesis       Date:  2000-02       Impact factor: 2.487

2.  Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice.

Authors:  Katsutaka Oishi; Morichika Konishi; Yusuke Murata; Nobuyuki Itoh
Journal:  Biochem Biophys Res Commun       Date:  2011-08-03       Impact factor: 3.575

3.  Thermogenic activation induces FGF21 expression and release in brown adipose tissue.

Authors:  Elayne Hondares; Roser Iglesias; Albert Giralt; Frank J Gonzalez; Marta Giralt; Teresa Mampel; Francesc Villarroya
Journal:  J Biol Chem       Date:  2011-02-13       Impact factor: 5.157

4.  Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21.

Authors:  Dionysios V Chartoumpekis; Ioannis G Habeos; Panos G Ziros; Agathoklis I Psyrogiannis; Venetsana E Kyriazopoulou; Athanasios G Papavassiliou
Journal:  Mol Med       Date:  2011-02-25       Impact factor: 6.354

5.  Selective expression of an aP2/Fatty Acid Binding Protein 4-Cre transgene in non-adipogenic tissues during embryonic development.

Authors:  Sumithra Urs; Anne Harrington; Lucy Liaw; Deena Small
Journal:  Transgenic Res       Date:  2006-09-02       Impact factor: 2.788

6.  Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

Authors:  Klementina Fon Tacer; Angie L Bookout; Xunshan Ding; Hiroshi Kurosu; George B John; Lei Wang; Regina Goetz; Moosa Mohammadi; Makoto Kuro-o; David J Mangelsdorf; Steven A Kliewer
Journal:  Mol Endocrinol       Date:  2010-07-28

7.  BetaKlotho is required for metabolic activity of fibroblast growth factor 21.

Authors:  Yasushi Ogawa; Hiroshi Kurosu; Masaya Yamamoto; Animesh Nandi; Kevin P Rosenblatt; Regina Goetz; Anna V Eliseenkova; Moosa Mohammadi; Makoto Kuro-o
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-23       Impact factor: 11.205

8.  FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho.

Authors:  Alexei Kharitonenkov; James D Dunbar; Holly A Bina; Stuart Bright; Julie S Moyers; Chen Zhang; Liyun Ding; Radmila Micanovic; Sean F Mehrbod; Michael D Knierman; John E Hale; Tamer Coskun; Armen B Shanafelt
Journal:  J Cell Physiol       Date:  2008-04       Impact factor: 6.384

9.  Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.

Authors:  Michael K Badman; Pavlos Pissios; Adam R Kennedy; George Koukos; Jeffrey S Flier; Eleftheria Maratos-Flier
Journal:  Cell Metab       Date:  2007-06       Impact factor: 27.287

10.  FGF21 promotes metabolic homeostasis via white adipose and leptin in mice.

Authors:  Murielle M Véniant; Clarence Hale; Joan Helmering; Michelle M Chen; Shanaka Stanislaus; Jim Busby; Steven Vonderfecht; Jing Xu; David J Lloyd
Journal:  PLoS One       Date:  2012-07-06       Impact factor: 3.240
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  176 in total

Review 1.  Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23.

Authors:  Chiara Degirolamo; Carlo Sabbà; Antonio Moschetta
Journal:  Nat Rev Drug Discov       Date:  2015-11-16       Impact factor: 84.694

2.  FGF21 Is an Exocrine Pancreas Secretagogue.

Authors:  Katie C Coate; Genaro Hernandez; Curtis A Thorne; Shengyi Sun; Thao D V Le; Kevin Vale; Steven A Kliewer; David J Mangelsdorf
Journal:  Cell Metab       Date:  2017-01-12       Impact factor: 27.287

Review 3.  A Land of Controversy: Fibroblast Growth Factor-23 and Uremic Cardiac Hypertrophy.

Authors:  Jing-Fu Bao; Pan-Pan Hu; Qin-Ying She; Aiqing Li
Journal:  J Am Soc Nephrol       Date:  2020-06-11       Impact factor: 10.121

4.  Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes.

Authors:  Rikke Kruse; Sara G Vienberg; Birgitte F Vind; Birgitte Andersen; Kurt Højlund
Journal:  Diabetologia       Date:  2017-07-18       Impact factor: 10.122

Review 5.  Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis.

Authors:  Lucas D BonDurant; Matthew J Potthoff
Journal:  Annu Rev Nutr       Date:  2018-05-04       Impact factor: 11.848

6.  Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients.

Authors:  J M Gallego-Escuredo; J Gómez-Ambrosi; V Catalan; P Domingo; M Giralt; G Frühbeck; F Villarroya
Journal:  Int J Obes (Lond)       Date:  2014-05-12       Impact factor: 5.095

7.  Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.

Authors:  Rucha Patel; Angie L Bookout; Lilia Magomedova; Bryn M Owen; Giulia P Consiglio; Makoto Shimizu; Yuan Zhang; David J Mangelsdorf; Steven A Kliewer; Carolyn L Cummins
Journal:  Mol Endocrinol       Date:  2014-12-11

8.  Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones.

Authors:  Andrew C Adams; Tamer Coskun; Christine C Cheng; Libbey S O Farrell; Susan L Dubois; Alexei Kharitonenkov
Journal:  Mol Metab       Date:  2013-05-29       Impact factor: 7.422

9.  Fibroblast growth factor 21: a novel long-acting hypoglycemic drug for canine diabetes.

Authors:  Xinghao Jiang; Shijie Liu; Yaoqun Wang; Ruonan Zhang; Yeboah Kwaku Opoku; Yinzhuo Xie; Deshan Li; Guiping Ren
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2020-11-20       Impact factor: 3.000

10.  Dietary Methionine Restriction Signals to the Brain Through Fibroblast Growth Factor 21 to Regulate Energy Balance and Remodeling of Adipose Tissue.

Authors:  Laura A Forney; Han Fang; Landon C Sims; Kirsten P Stone; Leighann Y Vincik; Alicia M Vick; Amanda N Gibson; David H Burk; Thomas W Gettys
Journal:  Obesity (Silver Spring)       Date:  2020-10       Impact factor: 5.002
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