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Literature DB >> 22958489

Repair problems in podocytes: Wnt, Notch, and glomerulosclerosis.

Abstract

Wnt/Ctnnb1 and Notch signaling play key roles in kidney development and epithelial cell specification. Recent reports have suggested that these pathways are reactivated in response to injury and in different disease conditions. Studies using genetically modified animal models showed that sustained activation of Notch and Wnt signaling in podocytes are causally related to albuminuria and glomerulosclerosis development. Here, we discuss the role and regulation of Wnt/Ctnnb1 and Notch signaling in podocytes.

Entities: Chemical Disease Gene Species

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Year: 2012 PMID： 22958489 PMCID： PMC3466477 DOI： 10.1016/j.semnephrol.2012.06.006

Source DB: PubMed Journal: Semin Nephrol ISSN： 0270-9295 Impact factor: 5.299

59 in total

1. Wnt signalling induces maturation of Paneth cells in intestinal crypts.

Authors: Johan H van Es; Philippe Jay; Alex Gregorieff; Marielle E van Gijn; Suzanne Jonkheer; Pantelis Hatzis; Andrea Thiele; Maaike van den Born; Harry Begthel; Thomas Brabletz; Makoto M Taketo; Hans Clevers
Journal: Nat Cell Biol Date: 2005-03-20 Impact factor: 28.824

Review 2. Podocyte damage damages podocytes: autonomous vicious cycle that drives local spread of glomerular sclerosis.

Authors: Iekuni Ichikawa; Ji Ma; Masaru Motojima; Taiji Matsusaka
Journal: Curr Opin Nephrol Hypertens Date: 2005-05 Impact factor: 2.894

3. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

Authors: Johan H van Es; Marielle E van Gijn; Orbicia Riccio; Maaike van den Born; Marc Vooijs; Harry Begthel; Miranda Cozijnsen; Sylvie Robine; Doug J Winton; Freddy Radtke; Hans Clevers
Journal: Nature Date: 2005-06-16 Impact factor: 49.962

4. Phenocopies induced with antisense RNA identify the wingless gene.

Authors: C V Cabrera; M C Alonso; P Johnston; R G Phillips; P A Lawrence
Journal: Cell Date: 1987-08-14 Impact factor: 41.582

5. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.

Authors: K Stark; S Vainio; G Vassileva; A P McMahon
Journal: Nature Date: 1994-12-15 Impact factor: 49.962

6. Functional consequences of integrin-linked kinase activation in podocyte damage.

Authors: Vicente de Paulo Castro Teixeira; Simone Monika Blattner; Min Li; Hans-Joachim Anders; Clemens David Cohen; Ilka Edenhofer; Novella Calvaresi; Monika Merkle; Maria Pia Rastaldi; Matthias Kretzler
Journal: Kidney Int Date: 2005-02 Impact factor: 10.612

Review 7. Beta-catenin: a key mediator of Wnt signaling.

Authors: K Willert; R Nusse
Journal: Curr Opin Genet Dev Date: 1998-02 Impact factor: 5.578

8. Inducible podocyte-specific gene expression in transgenic mice.

Authors: Tetsuya Shigehara; Concepcion Zaragoza; Chagriya Kitiyakara; Hideko Takahashi; Huiyan Lu; Marcus Moeller; Lawrence B Holzman; Jeffrey B Kopp
Journal: J Am Soc Nephrol Date: 2003-08 Impact factor: 10.121

9. The Wnt antagonist sFRP1 in colorectal tumorigenesis.

Authors: Germaine M Caldwell; Carolyn Jones; Karl Gensberg; Shamem Jan; Robert G Hardy; Philip Byrd; Shaheen Chughtai; Yvonne Wallis; Glenn M Matthews; Dion G Morton
Journal: Cancer Res Date: 2004-02-01 Impact factor: 12.701

10. Induction of kidney epithelial morphogenesis by cells expressing Wnt-1.

Authors: D Herzlinger; J Qiao; D Cohen; N Ramakrishna; A M Brown
Journal: Dev Biol Date: 1994-12 Impact factor: 3.582

21 in total

Review 1. Does Renal Repair Recapitulate Kidney Development?

Authors: Melissa Helen Little; Pamela Kairath
Journal: J Am Soc Nephrol Date: 2016-10-26 Impact factor: 10.121

2. Four-and-a-Half LIM Domains Protein 2 Is a Coactivator of Wnt Signaling in Diabetic Kidney Disease.

Authors: Szu-Yuan Li; Po-Hsun Huang; Der-Cherng Tarng; Tzu-Ping Lin; Wu-Chang Yang; Yen-Hwa Chang; An-Hang Yang; Chih-Ching Lin; Muh-Hwa Yang; Jaw-Wen Chen; Geert W Schmid-Schönbein; Shu Chien; Pao-Hsien Chu; Shing-Jong Lin
Journal: J Am Soc Nephrol Date: 2015-04-08 Impact factor: 10.121

Review 3. Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease.

Authors: Lili Zhou; Youhua Liu
Journal: Nat Rev Nephrol Date: 2015-06-09 Impact factor: 28.314

Review 4. Determining lineage relationships in kidney development and disease.

Authors: Melissa H Little; Sara E Howden; Kynan T Lawlor; Jessica M Vanslambrouck
Journal: Nat Rev Nephrol Date: 2021-09-30 Impact factor: 28.314

5. Increasing the level of peroxisome proliferator-activated receptor γ coactivator-1α in podocytes results in collapsing glomerulopathy.

Authors: Szu-Yuan Li; Jihwan Park; Chengxiang Qiu; Seung Hyeok Han; Matthew B Palmer; Zoltan Arany; Katalin Susztak
Journal: JCI Insight Date: 2017-07-20

6. Determination of relative Notch1 and gamma-secretase-related gene expression in puromycin-treated microdissected rat kidneys.

Authors: Damir Simic; Frank Simutis; Catherine Euler; Christina Thurby; W Mike Peden; R Todd Bunch; Gary Pilcher; Thomas Sanderson; Terry Van Vleet
Journal: Gene Expr Date: 2013

Review 7. Kick it up a notch: Notch signaling and kidney fibrosis.

Authors: Mariya T Sweetwyne; Jianling Tao; Katalin Susztak
Journal: Kidney Int Suppl (2011) Date: 2014-11

8. miR-135 family members mediate podocyte injury through the activation of Wnt/β-catenin signaling.

Authors: Xianggui Yang; Xiaoyan Wang; Fang Nie; Tianming Liu; Xuejing Yu; Honglian Wang; Qianyin Li; Rui Peng; Zhaomin Mao; Qin Zhou; Ge Li
Journal: Int J Mol Med Date: 2015-06-24 Impact factor: 4.101

Review 9. New insights into glomerular parietal epithelial cell activation and its signaling pathways in glomerular diseases.

Authors: Hua Su; Shan Chen; Fang-Fang He; Yu-Mei Wang; Philip Bondzie; Chun Zhang
Journal: Biomed Res Int Date: 2015-03-19 Impact factor: 3.411

10. Transforming growth factor-beta and the glomerular filtration barrier.

Authors: Ayesha Ghayur; Peter J Margetts
Journal: Kidney Res Clin Pract Date: 2013-03-01