BACKGROUND: Assistance Publique-Hôpitaux de Paris (APHP), the largest public health care institution in France (38 hospitals, 23,000 beds, serving 11.6 millions inhabitants) launched in 1993 a long term programme to control and survey multidrug resistant bacteria (MDR). FINDINGS: AP-HP MDR programme consisted in successive waves of actions: bundle measures to survey and control cross transmission of MRSA and extended-spectrum betalactamase producing enterobacteria (ESBL) in 1993, large campaign to promote the use of alcohol-based hand rub solution (ABHRS) in 2001, specific strategy to quickly control the spread of emerging MDR (vancomycin resistant Enterococcus, VRE; carbapenemase producing enterobacteria, CPE) in 2006, large campaign to decrease antibiotics consumption in 2006.Following this programme, the ABHRS consumption dramatically increased, the antibiotic consumption decreased by 10%, the incidence of MRSA, including MRSA bacteraemia, decreased by 2/3, all VRE and CPE events were rapidly controlled. However, the incidence of ESBL, mainly Klebsiella pneumoniae and Escherichia coli, that remained low and stable until 2003 increased markedly afterwards, justifying adapting our programme in the future. CONCLUSION: A sustained and coordinated strategy can lead to control multidrug resistant bacteria at the level of a large multihospital institution.
BACKGROUND: Assistance Publique-Hôpitaux de Paris (APHP), the largest public health care institution in France (38 hospitals, 23,000 beds, serving 11.6 millions inhabitants) launched in 1993 a long term programme to control and survey multidrug resistant bacteria (MDR). FINDINGS:AP-HP MDR programme consisted in successive waves of actions: bundle measures to survey and control cross transmission of MRSA and extended-spectrum betalactamase producing enterobacteria (ESBL) in 1993, large campaign to promote the use of alcohol-based hand rub solution (ABHRS) in 2001, specific strategy to quickly control the spread of emerging MDR (vancomycin resistant Enterococcus, VRE; carbapenemase producing enterobacteria, CPE) in 2006, large campaign to decrease antibiotics consumption in 2006.Following this programme, the ABHRS consumption dramatically increased, the antibiotic consumption decreased by 10%, the incidence of MRSA, including MRSA bacteraemia, decreased by 2/3, all VRE and CPE events were rapidly controlled. However, the incidence of ESBL, mainly Klebsiella pneumoniae and Escherichia coli, that remained low and stable until 2003 increased markedly afterwards, justifying adapting our programme in the future. CONCLUSION: A sustained and coordinated strategy can lead to control multidrug resistant bacteria at the level of a large multihospital institution.
Authors: Y Carmeli; M Akova; G Cornaglia; G L Daikos; J Garau; S Harbarth; G M Rossolini; M Souli; H Giamarellou Journal: Clin Microbiol Infect Date: 2010-02 Impact factor: 8.067
Authors: N Kassis-Chikhani; F Saliba; A Carbonne; S Neuville; D Decre; C Sengelin; C Guerin; N Gastiaburu; A Lavigne-Kriaa; C Boutelier; G Arlet; D Samuel; D Castaing; E Dussaix; V Jarlier Journal: Euro Surveill Date: 2010-11-18
Authors: A Carbonne; J M Thiolet; S Fournier; N Fortineau; N Kassis-Chikhani; I Boytchev; M Aggoune; J C Seguier; H Senechal; M P Tavolacci; B Coignard; P Astagneau; V Jarlier Journal: Euro Surveill Date: 2010-12-02
Authors: J-C Lucet; L Armand-Lefevre; J-J Laurichesse; A Macrez; E Papy; R Ruimy; C Deblangy; A Lozach; I Lolom; V Jarlier; A Andremont; C Leport Journal: J Hosp Infect Date: 2007-08-23 Impact factor: 3.926
Authors: Maria J G T Vehreschild; Miriam Haverkamp; Lena M Biehl; Sebastian Lemmen; Gerd Fätkenheuer Journal: Infection Date: 2018-09-03 Impact factor: 3.553
Authors: Irene Anna Lambraki; Shannon Elizabeth Majowicz; Elizabeth Jane Parmley; Didier Wernli; Anaïs Léger; Tiscar Graells; Melanie Cousins; Stephan Harbarth; Carolee Carson; Patrik Henriksson; Max Troell; Peter Søgaard Jørgensen Journal: JMIR Res Protoc Date: 2021-06-10