Literature DB >> 22956712

Antibasal Ganglia Antibodies and Antistreptolysin O in Noncomorbid ADHD.

Maddalena Toto1, Francesco Margari1, Marta Simone1, Francesco Craig1, Maria Giuseppina Petruzzelli1, Silvio Tafuri1, Lucia Margari2.   

Abstract

OBJECTIVE: An association between streptococcal infections, ABGA positivity, and no comorbidity ADHD (nc-ADHD) has been little investigated. The aim of this study was to evaluate the streptococcal infection frequency, defined entitled serum antistreptolysin O (ASO), and frequency of serum ABGA positivity in a sample of patients with nc-ADHD.
METHOD: In all 40 participants were investigated the ASO titer and ABGA.
RESULTS: The results showed that ABGA positivity was statistically significantly higher in patients affected by ADHD than in patients of a control group, and pathological values of ASO were statistically more frequent in the ADHD group than the control group.
CONCLUSION: These data suggest that streptococcal infections and autoimmune reactions against the basal ganglia are more frequent in ADHD patients than patients in a control group.
© The Author(s) 2012.

Entities:  

Keywords:  ADHD; antibasal ganglia antibodies; antistreptolysin O

Mesh:

Substances:

Year:  2012        PMID: 22956712     DOI: 10.1177/1087054712455505

Source DB:  PubMed          Journal:  J Atten Disord        ISSN: 1087-0547            Impact factor:   3.256


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