Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes.

Literature DB >> 22956455

Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes.

Nancy Campbell¹, Gavin W Collie, Stephen Neidle.

Abstract

Quadruplexes are higher-order structures formed by natural guanine-rich nucleic acid sequences. They may play a role in gene regulation and in telomere function. This article focuses on the crystallization of quadruplexes and their complexes with small-molecule ligands. Protocols for successful crystallization, as used in the author's laboratory, are described in detail.

Entities: Chemical

Mesh：

Substances：
Ligands
RNA
DNA

Year: 2012 PMID： 22956455 DOI： 10.1002/0471142700.nc1706s50

Source DB: PubMed Journal: Curr Protoc Nucleic Acid Chem ISSN： 1934-9270

Keyword Cloud
Cited

11 in total

1. Harnessing intrinsic fluorescence for typing of secondary structures of DNA.

Authors: Michela Zuffo; Aurélie Gandolfini; Brahim Heddi; Anton Granzhan
Journal: Nucleic Acids Res Date: 2020-06-19 Impact factor: 16.971

2. Selective recognition of c-MYC Pu22 G-quadruplex by a fluorescent probe.

Authors: Qianqian Zhai; Chao Gao; Jieqin Ding; Yashu Zhang; Barira Islam; Wenxian Lan; Haitao Hou; Hua Deng; Jun Li; Zhe Hu; Hany I Mohamed; Shengzhen Xu; Chunyang Cao; Shozeb M Haider; Dengguo Wei
Journal: Nucleic Acids Res Date: 2019-03-18 Impact factor: 16.971

3. Thermodynamic characterization of human telomere quadruplex unfolding.

Authors: R Buscaglia; R D Gray; J B Chaires
Journal: Biopolymers Date: 2013-12 Impact factor: 2.505

4. Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding.

Authors: Philip J Smaldino; Eric D Routh; Jung H Kim; Banabihari Giri; Steven D Creacy; Roy R Hantgan; Steven A Akman; James P Vaughn
Journal: PLoS One Date: 2015-07-14 Impact factor: 3.240

5. Loop flexibility in human telomeric quadruplex small-molecule complexes.

Authors: Gavin W Collie; Nancy H Campbell; Stephen Neidle
Journal: Nucleic Acids Res Date: 2015-05-04 Impact factor: 16.971

6. Conformational diversity of single-stranded DNA from bacterial repetitive extragenic palindromes: Implications for the DNA recognition elements of transposases.

Authors: Tatsiana Charnavets; Jaroslav Nunvar; Iva Nečasová; Jens Völker; Kenneth J Breslauer; Bohdan Schneider
Journal: Biopolymers Date: 2015-10 Impact factor: 2.505

Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes.

1. Harnessing intrinsic fluorescence for typing of secondary structures of DNA.

2. Selective recognition of c-MYC Pu22 G-quadruplex by a fluorescent probe.

3. Thermodynamic characterization of human telomere quadruplex unfolding.

4. Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding.

5. Loop flexibility in human telomeric quadruplex small-molecule complexes.

6. Conformational diversity of single-stranded DNA from bacterial repetitive extragenic palindromes: Implications for the DNA recognition elements of transposases.

7. Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations.

8. RNA G-quadruplexes: emerging mechanisms in disease.

9. Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding.

Review 10. Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents.