Literature DB >> 22956130

Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling.

Jufang Shan1, Jie J Zheng.   

Abstract

Virtual ligand screening is a powerful technique to identify potential hits of targets and to increase hit rates. Here, we describe how we used this technique combined with NMR (15)N HSQC experiments to obtain small molecules that bind to the PDZ domain of Dvl targeting the Wnt signaling pathway.

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Year:  2012        PMID： 22956130      PMCID： PMC3964848          DOI： 10.1007/978-1-62703-008-3_2

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  30 in total

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