Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Biological activity evaluation and structure-activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer.

Literature DB >> 22954735

Biological activity evaluation and structure-activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer.

Weixia Li¹, Nianguang Li, Yuping Tang, Baoquan Li, Li Liu, Xu Zhang, Haian Fu, Jin-Ao Duan.

Abstract

The anticancer activities of alkyl esters and NO-donors of ferulic acid (FA) and caffeic acid (CA) were assessed by a high-throughout screening (HTS) method, and the structure-activity relationships were described. CA alkyl esters had better anticancer activities than FA alkyl esters with the same alkyl substituent. Mono-nitrates and phenylfuroxan nitrates were more potent than the dual nitrates. Phenylsulfonylfuroxan nitrates of FA, especially compounds 8b-8d, exhibited more potent activities in anticancer.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2012 PMID： 22954735 DOI： 10.1016/j.bmcl.2012.08.038

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

12 in total

1. In vitro biological screening of the anticholinesterase and antiproliferative activities of medicinal plants belonging to Annonaceae.

Authors: A S N Formagio; M C Vieira; C R F Volobuff; M S Silva; A I Matos; C A L Cardoso; M A Foglio; J E Carvalho
Journal: Braz J Med Biol Res Date: 2015-02-13 Impact factor: 2.590

2. Matsuda-Heck reaction with arenediazonium tosylates in water.

Authors: Ksenia V Kutonova; Marina E Trusova; Andrey V Stankevich; Pavel S Postnikov; Victor D Filimonov
Journal: Beilstein J Org Chem Date: 2015-03-16 Impact factor: 2.883

3. Phenolic Profile and In vitro Antioxidant Activity of Endemic Bulgarian Carduus Species.

Authors: Ivanka Dimitrova-Dyulgerova; Iliya Zhelev; Dasha Mihaylova
Journal: Pharmacogn Mag Date: 2015-10 Impact factor: 1.085

4. Transformation of Lactuca sativa L. with rol C gene results in increased antioxidant potential and enhanced analgesic, anti-inflammatory and antidepressant activities in vivo.

Authors: Hammad Ismail; Erum Dilshad; Mohammad Tahir Waheed; Moniba Sajid; Waqas Khan Kayani; Bushra Mirza
Journal: 3 Biotech Date: 2016-10-05 Impact factor: 2.406

5. Isopropyl Caffeate: A Caffeic Acid Derivative-Antioxidant Potential and Toxicity.

Authors: Andressa Brito Lira; Camila de Albuquerque Montenegro; Kardilandia Mendes de Oliveira; Abrahão Alves de Oliveira Filho; Alexandre Rolim da Paz; Marianna Oliveira de Araújo; Damião Pergentino de Sousa; Cynthia Layse Ferreira de Almeida; Teresinha Gonçalves da Silva; Caliandra Maria Bezerra Luna Lima; Margareth de Fátima Formiga Melo Diniz; Hilzeth de Luna Freire Pessôa
Journal: Oxid Med Cell Longev Date: 2018-04-19 Impact factor: 6.543

6. A Ferulic Acid Derivative FXS-3 Inhibits Proliferation and Metastasis of Human Lung Cancer A549 Cells via Positive JNK Signaling Pathway and Negative ERK/p38, AKT/mTOR and MEK/ERK Signaling Pathways.

Authors: Shi-Jun Yue; Peng-Xuan Zhang; Yue Zhu; Nian-Guang Li; Yan-Yan Chen; Jia-Jia Li; Sai Zhang; Ru-Yi Jin; Hao Yan; Xu-Qin Shi; Yu-Ping Tang; Jin-Ao Duan
Journal: Molecules Date: 2019-06-08 Impact factor: 4.411

Biological activity evaluation and structure-activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer.

1. In vitro biological screening of the anticholinesterase and antiproliferative activities of medicinal plants belonging to Annonaceae.

2. Matsuda-Heck reaction with arenediazonium tosylates in water.

3. Phenolic Profile and In vitro Antioxidant Activity of Endemic Bulgarian Carduus Species.

4. Transformation of Lactuca sativa L. with rol C gene results in increased antioxidant potential and enhanced analgesic, anti-inflammatory and antidepressant activities in vivo.

5. Isopropyl Caffeate: A Caffeic Acid Derivative-Antioxidant Potential and Toxicity.

6. A Ferulic Acid Derivative FXS-3 Inhibits Proliferation and Metastasis of Human Lung Cancer A549 Cells via Positive JNK Signaling Pathway and Negative ERK/p38, AKT/mTOR and MEK/ERK Signaling Pathways.

Review 7. Caffeates and Caffeamides: Synthetic Methodologies and Their Antioxidant Properties.

8. FAEE exerts a protective effect against osteoporosis by regulating the MAPK signalling pathway.

9. Efficient syntheses of climate relevant isoprene nitrates and (1R,5S)-(-)-myrtenol nitrate.

10. Piplartine Analogues and Cytotoxic Evaluation against Glioblastoma.