Literature DB >> 2295446

5-Fluorouracil neurotoxicity.

D H Moore1, W C Fowler, L S Crumpler.   

Abstract

Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.

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Year:  1990        PMID： 2295446     DOI： 10.1016/0090-8258(90)90127-7

Source DB:  PubMed          Journal:  Gynecol Oncol        ISSN： 0090-8258            Impact factor:   5.482


  9 in total

1.  Seizures following subconjunctival 5-FU therapy.

Authors:  René Hoehn; Julia Lamparter; Norbert Pfeiffer; Urs Vossmerbaeumer
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2010-03-30       Impact factor: 3.117

2.  Common emergencies in cancer medicine: infectious and treatment-related syndromes, Part II.

Authors:  C R Thomas; K J Stelzer; J G Douglas; W J Koh; L V Wood; R Panicker
Journal:  J Natl Med Assoc       Date:  1994-11       Impact factor: 1.798

3.  Thiamine deficiency in patients with B-chronic lymphocytic leukaemia: a pilot study.

Authors:  H Seligmann; R Levi; A M Konijn; M Prokocimer
Journal:  Postgrad Med J       Date:  2001-09       Impact factor: 2.401

Review 4.  Central nervous system toxicity from cancer treatment.

Authors:  Terri Armstrong; Mark R Gilbert
Journal:  Curr Oncol Rep       Date:  2004-01       Impact factor: 5.075

5.  The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate.

Authors:  M Arellano; M Malet-Martino; R Martino; P Gires
Journal:  Br J Cancer       Date:  1998       Impact factor: 7.640

6.  A case of neurotoxicity following 5-fluorouracil-based chemotherapy.

Authors:  Seung Seog Ki; Jin Mo Jeong; Seong Ho Kim; Sook Hyang Jeong; Jin Hyuk Lee; Chul Ju Han; You Cheol Kim; Jhin Oh Lee; Young Joon Hong
Journal:  Korean J Intern Med       Date:  2002-03       Impact factor: 2.884

7.  Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy.

Authors:  Pornthip Chaisawang; Apiwat Sirichoat; Wunnee Chaijaroonkhanarak; Wanassanun Pannangrong; Bungorn Sripanidkulchai; Peter Wigmore; Jariya Umka Welbat
Journal:  PLoS One       Date:  2017-07-10       Impact factor: 3.240

8.  The confused cancer patient: a case of 5-fluorouracil-induced encephalopathy.

Authors:  W Y Cheung; R A Fralick; S Cheng
Journal:  Curr Oncol       Date:  2008-10       Impact factor: 3.677

9.  Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system.

Authors:  Ruolan Han; Yin M Yang; Joerg Dietrich; Anne Luebke; Margot Mayer-Pröschel; Mark Noble
Journal:  J Biol       Date:  2008-04-22
  9 in total

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