Literature DB >> 2295128

Inhibition of N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats by ellagic acid.

S Mandal1, G D Stoner.   

Abstract

In this report, we describe the ability of ellagic acid (EA), a phenolic compound present in a number of fruits and nuts, to inhibit N-nitrosobenzylmethylamine (NBMA) tumorigenesis in the rat esophagus. When administered in a semi-purified diet at concentrations of 0.4 and 4 g/kg, EA produced a significant (21-55%) decrease in the average number of NBMA-induced esophageal tumors after 20 and 27 weeks of the bioassay. EA exhibited inhibitory effects toward preneoplastic lesions as well as neoplastic lesions. Tumors were not observed in vehicle-control rats or in rats that received EA alone.

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Year:  1990        PMID： 2295128     DOI： 10.1093/carcin/11.1.55

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  27 in total

1.  Ellagic acid coordinately attenuates Wnt/β-catenin and NF-κB signaling pathways to induce intrinsic apoptosis in an animal model of oral oncogenesis.

Authors:  Prabukumar Anitha; Ramamurthi Vidya Priyadarsini; Krishnamurthy Kavitha; Paranthaman Thiyagarajan; Siddavaram Nagini
Journal:  Eur J Nutr       Date:  2011-12-11       Impact factor: 5.614

2.  Randomized phase II trial of lyophilized strawberries in patients with dysplastic precancerous lesions of the esophagus.

Authors:  Tong Chen; Fei Yan; Jiaming Qian; Mingzhou Guo; Hongbing Zhang; Xiaofei Tang; Fang Chen; Gary D Stoner; Xiaomin Wang
Journal:  Cancer Prev Res (Phila)       Date:  2011-12-01

3.  Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats.

Authors:  Gary D Stoner; Li-Shu Wang; Claire Seguin; Claudio Rocha; Kristen Stoner; Steven Chiu; A Douglas Kinghorn
Journal:  Pharm Res       Date:  2010-03-16       Impact factor: 4.200

4.  Structural and Kinetic Studies of the Effect of Guanine N7 Alkylation and Metal Cofactors on DNA Replication.

Authors:  Yi Kou; Myong-Chul Koag; Seongmin Lee
Journal:  Biochemistry       Date:  2018-08-13       Impact factor: 3.162

Review 5.  Multiple models for Rosaceae genomics.

Authors:  Vladimir Shulaev; Schuyler S Korban; Bryon Sosinski; Albert G Abbott; Herb S Aldwinckle; Kevin M Folta; Amy Iezzoni; Dorrie Main; Pere Arús; Abhaya M Dandekar; Kim Lewers; Susan K Brown; Thomas M Davis; Susan E Gardiner; Daniel Potter; Richard E Veilleux
Journal:  Plant Physiol       Date:  2008-05-16       Impact factor: 8.340

6.  Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms.

Authors:  Gary D Stoner; Tong Chen; Laura A Kresty; Robeena M Aziz; Tiffany Reinemann; Ronald Nines
Journal:  Nutr Cancer       Date:  2006       Impact factor: 2.900

Review 7.  Cancer prevention with freeze-dried berries and berry components.

Authors:  Gary D Stoner; Li-Shu Wang; Nancy Zikri; Tong Chen; Stephen S Hecht; Chuanshu Huang; Christine Sardo; John F Lechner
Journal:  Semin Cancer Biol       Date:  2007-05-10       Impact factor: 15.707

Review 8.  Chemoprevention of esophageal squamous cell carcinoma.

Authors:  Gary D Stoner; Li-Shu Wang; Tong Chen
Journal:  Toxicol Appl Pharmacol       Date:  2007-03-15       Impact factor: 4.219

9.  Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate.

Authors:  Gary D Stoner; Alan A Dombkowski; Rashmeet K Reen; Daniela Cukovic; Sridevi Salagrama; Li-Shu Wang; John F Lechner
Journal:  Cancer Res       Date:  2008-08-01       Impact factor: 12.701

10.  Urolithin A suppresses the proliferation of endometrial cancer cells by mediating estrogen receptor-α-dependent gene expression.

Authors:  Wei Zhang; Jo-Hsin Chen; Irene Aguilera-Barrantes; Chung-Wai Shiau; Xiugui Sheng; Li-Shu Wang; Gary D Stoner; Yi-Wen Huang
Journal:  Mol Nutr Food Res       Date:  2016-07-25       Impact factor: 5.914
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