| Literature DB >> 22951041 |
Yong He1, Jing Li, Nin Yin, Prudencio S Herradura, Larry Martel, Yanzhi Zhang, Andre L Pearson, Vidya Kulkarni, Carmela Mascio, Karen Howland, Jared A Silverman, Dennis D Keith, Chester A Metcalf.
Abstract
Daptomycin was shown to interact in vitro with pulmonary surfactant leading to reduction of its antibacterial activity. We report herein the preparation and anti-staphylococcal activity of a series of daptomycin analogs with reduced pulmonary surfactant interaction by replacing tryptophan with various amino acids.Entities:
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Year: 2012 PMID： 22951041 DOI： 10.1016/j.bmcl.2012.08.013
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823