AIM: The aim of this study was to compare the characteristics of older and younger patients with suspected paracetamol toxicity. METHODS: A retrospective audit of the medical records of older (≥65 years, n = 25) and younger (20-30 years, n = 50) patients with a detectable paracetamol level at a Sydney hospital. RESULTS: Older patients showed a different clinical pattern of suspected paracetamol toxicity and were more likely than younger patients to have multifactorial elevation of liver function tests. Additionally, older age was more likely to be associated with chronic therapeutic paracetamol dosing (71% older, 6% younger, P < 0.001), or with accidental toxic exposure (90% older, 29% younger, P < 0.001), while younger patients were more likely to have a deliberate high-dose exposure (10% older, 71% younger, P < 0.001). CONCLUSIONS: The age-related differences in paracetamol exposure, paracetamol levels and liver function tests described in this population should be considered when ordering and interpreting paracetamol levels.
AIM: The aim of this study was to compare the characteristics of older and younger patients with suspected paracetamoltoxicity. METHODS: A retrospective audit of the medical records of older (≥65 years, n = 25) and younger (20-30 years, n = 50) patients with a detectable paracetamol level at a Sydney hospital. RESULTS: Older patients showed a different clinical pattern of suspected paracetamoltoxicity and were more likely than younger patients to have multifactorial elevation of liver function tests. Additionally, older age was more likely to be associated with chronic therapeutic paracetamol dosing (71% older, 6% younger, P < 0.001), or with accidental toxic exposure (90% older, 29% younger, P < 0.001), while younger patients were more likely to have a deliberate high-dose exposure (10% older, 71% younger, P < 0.001). CONCLUSIONS: The age-related differences in paracetamol exposure, paracetamol levels and liver function tests described in this population should be considered when ordering and interpreting paracetamol levels.
Authors: Alice E Kane; Sarah J Mitchell; John Mach; Aniko Huizer-Pajkos; Catriona McKenzie; Brett Jones; Victoria Cogger; David G Le Couteur; Rafael de Cabo; Sarah N Hilmer Journal: Exp Gerontol Date: 2015-11-23 Impact factor: 4.032
Authors: John Mach; Aniko Huizer-Pajkos; Victoria C Cogger; Catriona McKenzie; David G Le Couteur; Brett E Jones; Rafael de Cabo; Sarah N Hilmer Journal: J Gerontol A Biol Sci Med Sci Date: 2013-07-17 Impact factor: 6.053
Authors: Alice Elizabeth Kane; Aniko Huizer-Pajkos; John Mach; Catriona McKenzie; Sarah Jayne Mitchell; Rafael de Cabo; Brett Jones; Victoria Cogger; David G Le Couteur; Sarah Nicole Hilmer Journal: Fundam Clin Pharmacol Date: 2016-02-17 Impact factor: 2.748