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Literature DB >> 22950366

Thrombin inhibitors from the freshwater cyanobacterium Anabaena compacta.

Andrea Roxanne J Anas¹, Takaya Kisugi, Taiki Umezawa, Fuyuhiko Matsuda, Marc R Campitelli, Ronald J Quinn, Tatsufumi Okino.

Abstract

Bioassay-guided investigation of the cyanobacterium Anabaena compacta extracts afforded spumigin J (1) and the known thrombin inhibitor spumigin A (2). The absolute configuration of 1 was analyzed by advanced Marfey's methodology. Compounds 1 and 2 inhibited thrombin with EC(50) values of 4.9 and 2.1 μM, and 0.7 and 0.2 μM in the cathepsin B inhibitory assay, respectively. The MM-GBSA methodology predicted spumigin A with 2S-4-methylproline as the better thrombin inhibitor.

Entities: Chemical Species

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Year: 2012 PMID： 22950366 DOI： 10.1021/np300282a

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

8 in total

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2. Enantioselective Synthesis of D-α-Amino Amides from Aliphatic Aldehydes.

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3. Determination of FVIIa-sTF Inhibitors in Toxic Microcystis Cyanobacteria by LC-MS Technique.

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4. Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp. CENA543.

Authors: Jouni Jokela; Lassi M P Heinilä; Tânia K Shishido; Matti Wahlsten; David P Fewer; Marli F Fiore; Hao Wang; Esa Haapaniemi; Perttu Permi; Kaarina Sivonen
Journal: Front Microbiol Date: 2017-10-09 Impact factor: 5.640

5. Cyanobacterial Toxins and Peptides in Lake Vegoritis, Greece.

Authors: Sevasti-Kiriaki Zervou; Kimon Moschandreou; Aikaterina Paraskevopoulou; Christophoros Christophoridis; Elpida Grigoriadou; Triantafyllos Kaloudis; Theodoros M Triantis; Vasiliki Tsiaoussi; Anastasia Hiskia
Journal: Toxins (Basel) Date: 2021-06-01 Impact factor: 4.546

Thrombin inhibitors from the freshwater cyanobacterium Anabaena compacta.

Review 1. Algal Toxic Compounds and Their Aeroterrestrial, Airborne and other Extremophilic Producers with Attention to Soil and Plant Contamination: A Review.

2. Enantioselective Synthesis of D-α-Amino Amides from Aliphatic Aldehydes.

3. Determination of FVIIa-sTF Inhibitors in Toxic Microcystis Cyanobacteria by LC-MS Technique.

4. Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp. CENA543.

5. Cyanobacterial Toxins and Peptides in Lake Vegoritis, Greece.

6. New structural variants of aeruginosin produced by the toxic bloom forming cyanobacterium Nodularia spumigena.

7. FVIIa-sTF and Thrombin Inhibitory Activities of Compounds Isolated from Microcystis aeruginosa K-139.

8. Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity.