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Literature DB >> 22949936

Analysis of whole genomic expression profiles and screening of the key signaling pathways associated with pancreatic cancer.

Chengzhi He¹, Hua Jiang, Shasha Geng, Haihui Sheng, Xiaoying Shen, Xiaoyan Zhang, Shizhang Zhu, Ximei Chen, Changqing Yang, Hengjun Gao.

Abstract

The tumorigenesis of pancreatic cancer is thought to be a complex process. Investigation of the molecular mechanism of pancreatic cancer and exploring the specific markers for early diagnosis and specific targets of therapy is a key point to prevent and treat pancreatic cancer effectively and to improve their prognosis. In this study, expression profiles experiment was performed using Agilent human whole genomic oligonucleotide microarrays with 41,000 genes. Differentially expressed genes related with pancreatic cancer were screened, and analyzed further by GO term analysis and KEGG Pathway analysis. Our results showed that there were 1276 differentially expressed genes associated with pancreatic cancer. 691 genes were up regulated and 585 were down regulated in pancreatic cancer group. The present study confirmed that the occurrence of pancreatic cancer was involved in multiple-gene interaction. In addition, our study found that pancreatic cancer was related to an activation of the mTOR signaling pathway and renal cell carcinoma pathway.

Entities: Chemical Disease Gene Species

Keywords: Pancreatic cancer; gene expression profile; microarray; signaling pathway

Mesh：

Substances：

Year: 2012 PMID： 22949936 PMCID： PMC3430114

Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625

40 in total

1. Mutational analysis of PDPK1 kinase domain in gastric, colorectal and lung carcinomas.

Authors: Jong Woo Lee; Young Hwa Soung; Su Young Kim; Suk Woo Nam; Won Sang Park; Jung Young Lee; Nam Jin Yoo; Sug Hyung Lee
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2. Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells.

Authors: Maen Abdelrahim; Cheryl H Baker; James L Abbruzzese; David Sheikh-Hamad; Shengxi Liu; Sung Dae Cho; Kyungsil Yoon; Stephen Safe
Journal: Cancer Res Date: 2007-04-01 Impact factor: 12.701

3. 4E binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers.

Authors: M E Martín; M I Pérez; C Redondo; M I Alvarez; M Salinas; J L Fando
Journal: Int J Biochem Cell Biol Date: 2000-06 Impact factor: 5.085

4. Comparison of gene expression profiles between Opisthorchis viverrini and non-Opisthorchis viverrini associated human intrahepatic cholangiocarcinoma.

Authors: Natini Jinawath; Yaovalux Chamgramol; Yoichi Furukawa; Kazutaka Obama; Tatsuhiko Tsunoda; Banchob Sripa; Chawalit Pairojkul; Yusuke Nakamura
Journal: Hepatology Date: 2006-10 Impact factor: 17.425

5. Cationic cell-penetrating peptides interfere with TNF signalling by induction of TNF receptor internalization.

Authors: Mariola Fotin-Mleczek; Stefan Welte; Oliver Mader; Falk Duchardt; Rainer Fischer; Hansjörg Hufnagel; Peter Scheurich; Roland Brock
Journal: J Cell Sci Date: 2005-08-01 Impact factor: 5.285

6. Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection.

Authors: Toru Nakamura; Yoichi Furukawa; Hidewaki Nakagawa; Tatsuhiko Tsunoda; Hiroaki Ohigashi; Kohei Murata; Osamu Ishikawa; Kazuhisa Ohgaki; Nobuichi Kashimura; Masaki Miyamoto; Satoshi Hirano; Satoshi Kondo; Hiroyuki Katoh; Yusuke Nakamura; Toyomasa Katagiri
Journal: Oncogene Date: 2004-03-25 Impact factor: 9.867

7. Expression of transforming growth factor beta1, beta2, and beta3 in chronic, cancer-associated, obstructive pancreatitis.

Authors: Yuki Fukumura; Toshio Kumasaka; Keiko Mitani; Kanae Karita; Koichi Suda
Journal: Arch Pathol Lab Med Date: 2006-03 Impact factor: 5.534

8. Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma.

Authors: Liliana Soroceanu; Samir Kharbanda; Ruihuan Chen; Robert H Soriano; Ken Aldape; Anjan Misra; Jiping Zha; William F Forrest; Janice M Nigro; Zora Modrusan; Burt G Feuerstein; Heidi S Phillips
Journal: Proc Natl Acad Sci U S A Date: 2007-02-20 Impact factor: 11.205

Analysis of whole genomic expression profiles and screening of the key signaling pathways associated with pancreatic cancer.

1. Mutational analysis of PDPK1 kinase domain in gastric, colorectal and lung carcinomas.

2. Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells.

3. 4E binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers.

4. Comparison of gene expression profiles between Opisthorchis viverrini and non-Opisthorchis viverrini associated human intrahepatic cholangiocarcinoma.

5. Cationic cell-penetrating peptides interfere with TNF signalling by induction of TNF receptor internalization.

6. Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection.

7. Expression of transforming growth factor beta1, beta2, and beta3 in chronic, cancer-associated, obstructive pancreatitis.

8. Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma.

9. Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells.

Review 10. Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer.

Review 1. Contribution of bioinformatics prediction in microRNA-based cancer therapeutics.

2. Differential expression profiling of microRNAs in para-carcinoma, carcinoma and relapse human pancreatic cancer.

3. Cytoplasmic HSP90α expression is associated with perineural invasion in pancreatic cancer.

Review 4. Pancreatic Cancer, A Mis-interpreter of the Epigenetic Language.

5. Network of microRNAs-mRNAs interactions in pancreatic cancer.