BACKGROUND: A high prevalence of vitamin D insufficiency has been found in the general population, in patients with chronic kidney disease and in kidney transplant patients. During winter there is a higher prevalence of vitamin D insufficiency due to the lack of solar ultraviolet B (UVB) exposure. Kidney transplant patients are advised to avoid sun exposure because of their high risk of skin cancer. This is considered to be one of the main reasons for the very high prevalence of vitamin D insufficiency in these patients. Whether circannual rhythm of vitamin D is totally reversed in kidney transplant patients is not known. METHODS: In this single centre prospective observational study, 50 kidney transplant patients visiting our outpatient clinic in January and February 2011 were included. Serum concentration of 25-hydroxvitamin D (25[OH]D), 1-25-hydroxvitamin D (1-25[OH]D) and intact parathormone (iPTH) were measured at study entry and 6 months later in summer. RESULTS: A total of 90% (45/50) of the study population had vitamin D deficiency 25(OH)D (<50 nmol/l) during winter. There was a rise of 25(OH)D in 94% (47/50) of patients from winter to summer (p <0.0001) leading to a decline of 25(OH)D deficiency from 90 to 60%, to a rise of 25(OH)D insufficiency from 6 to 26% and normal 25(OH)D from 4 to 14%, respectively (p = 0.0024). CONCLUSIONS: Vitamin D insufficiency during winter is very common in kidney transplant patients at our centre. Despite avoidance of exposure to UVB there is a preserved circannual rhythm of vitamin D in kidney transplant patients.
BACKGROUND: A high prevalence of vitamin Dinsufficiency has been found in the general population, in patients with chronic kidney disease and in kidney transplant patients. During winter there is a higher prevalence of vitamin Dinsufficiency due to the lack of solar ultraviolet B (UVB) exposure. Kidney transplant patients are advised to avoid sun exposure because of their high risk of skin cancer. This is considered to be one of the main reasons for the very high prevalence of vitamin Dinsufficiency in these patients. Whether circannual rhythm of vitamin D is totally reversed in kidney transplant patients is not known. METHODS: In this single centre prospective observational study, 50 kidney transplant patients visiting our outpatient clinic in January and February 2011 were included. Serum concentration of 25-hydroxvitamin D (25[OH]D), 1-25-hydroxvitamin D (1-25[OH]D) and intact parathormone (iPTH) were measured at study entry and 6 months later in summer. RESULTS: A total of 90% (45/50) of the study population had vitamin D deficiency 25(OH)D (<50 nmol/l) during winter. There was a rise of 25(OH)D in 94% (47/50) of patients from winter to summer (p <0.0001) leading to a decline of 25(OH)D deficiency from 90 to 60%, to a rise of 25(OH)D insufficiency from 6 to 26% and normal 25(OH)D from 4 to 14%, respectively (p = 0.0024). CONCLUSIONS:Vitamin Dinsufficiency during winter is very common in kidney transplant patients at our centre. Despite avoidance of exposure to UVB there is a preserved circannual rhythm of vitamin D in kidney transplant patients.
Authors: Benjamin Sakem; Cristina Nock; Zeno Stanga; Pedro Medina; Urs E Nydegger; Martin Risch; Lorenz Risch Journal: BMC Med Date: 2013-08-01 Impact factor: 8.775
Authors: Giuseppe Cianciolo; Maria Cappuccilli; Francesco Tondolo; Lorenzo Gasperoni; Fulvia Zappulo; Simona Barbuto; Francesca Iacovella; Diletta Conte; Irene Capelli; Gaetano La Manna Journal: Nutrients Date: 2021-04-25 Impact factor: 5.717
Authors: Paolo Molinari; Carlo Maria Alfieri; Deborah Mattinzoli; Mariarosaria Campise; Angela Cervesato; Silvia Malvica; Evaldo Favi; Piergiorgio Messa; Giuseppe Castellano Journal: Front Med (Lausanne) Date: 2022-03-10