CONTEXT: Screening criteria for abnormal growth in children are traditionally based on height-for-age, height distance from target height (TH), and change in growth rate. However, there is no consensus on the optimal screening limits. OBJECTIVE: Our objective was to first develop new population-based and age-specific cutoffs for these three screening parameters and, second, to validate their performance in screening by using Turner syndrome (TS) as a model. DESIGN, PATIENTS, AND MAIN OUTCOME MEASURE: Reference values for the height distance from TH and growth rate were defined in a total of 14,189 healthy girls aged 0-18 yr with 147,469 height measurements. The best formula for TH calculation was TH sd score = 0.79 × mid-parental height sd score - 0.15. We also calculated age-specific limits for the distance from TH and limits for growth rate that were freely scalable between age range 0-12 yr. Longitudinal growth data of a cohort including 124 TS girls were evaluated with receiver operating characteristic analysis against the reference population. RESULTS: The screening accuracy for TS was excellent when we combined all three screening parameters. Sensitivity was 97% and specificity 96% for all TS girls and 100% and 95% for 45,XO TS girls, respectively. The detection rate was 68% for all and 76% for 45,XO TS girls with 99% specificity by the age of 2 yr. CONCLUSION: These new population-based screening rules for TS are sensitive and specific, but their use is complex, and therefore their efficient use requires computerization.
CONTEXT: Screening criteria for abnormal growth in children are traditionally based on height-for-age, height distance from target height (TH), and change in growth rate. However, there is no consensus on the optimal screening limits. OBJECTIVE: Our objective was to first develop new population-based and age-specific cutoffs for these three screening parameters and, second, to validate their performance in screening by using Turner syndrome (TS) as a model. DESIGN, PATIENTS, AND MAIN OUTCOME MEASURE: Reference values for the height distance from TH and growth rate were defined in a total of 14,189 healthy girls aged 0-18 yr with 147,469 height measurements. The best formula for TH calculation was TH sd score = 0.79 × mid-parental height sd score - 0.15. We also calculated age-specific limits for the distance from TH and limits for growth rate that were freely scalable between age range 0-12 yr. Longitudinal growth data of a cohort including 124 TS girls were evaluated with receiver operating characteristic analysis against the reference population. RESULTS: The screening accuracy for TS was excellent when we combined all three screening parameters. Sensitivity was 97% and specificity 96% for all TS girls and 100% and 95% for 45,XO TS girls, respectively. The detection rate was 68% for all and 76% for 45,XO TS girls with 99% specificity by the age of 2 yr. CONCLUSION: These new population-based screening rules for TS are sensitive and specific, but their use is complex, and therefore their efficient use requires computerization.
Authors: Paulo F Collett-Solberg; Geoffrey Ambler; Philippe F Backeljauw; Martin Bidlingmaier; Beverly M K Biller; Margaret C S Boguszewski; Pik To Cheung; Catherine Seut Yhoke Choong; Laurie E Cohen; Pinchas Cohen; Andrew Dauber; Cheri L Deal; Chunxiu Gong; Yukihiro Hasegawa; Andrew R Hoffman; Paul L Hofman; Reiko Horikawa; Alexander A L Jorge; Anders Juul; Peter Kamenický; Vaman Khadilkar; John J Kopchick; Berit Kriström; Maria de Lurdes A Lopes; Xiaoping Luo; Bradley S Miller; Madhusmita Misra; Irene Netchine; Sally Radovick; Michael B Ranke; Alan D Rogol; Ron G Rosenfeld; Paul Saenger; Jan M Wit; Joachim Woelfle Journal: Horm Res Paediatr Date: 2019-09-12 Impact factor: 2.852
Authors: Yasmine Ouarezki; Filiz Mine Cizmecioglu; Chourouk Mansour; Jeremy Huw Jones; Emma Jane Gault; Avril Mason; Malcolm D C Donaldson Journal: Eur J Pediatr Date: 2017-12-18 Impact factor: 3.183
Authors: Jan M. Wit; Asma Deeb; Bassam Bin-Abbas; Angham Al Mutair; Ekaterina Koledova; Martin O. Savage Journal: J Clin Res Pediatr Endocrinol Date: 2019-07-09
Authors: José I. Labarta; Michael B. Ranke; Mohamad Maghnie; David Martin; Laura Guazzarotti; Roland Pfäffle; Ekaterina Koledova; Jan M. Wit Journal: J Clin Res Pediatr Endocrinol Date: 2020-10-02
Authors: Mohamad Maghnie; José I Labarta; Ekaterina Koledova; Tilman R Rohrer Journal: Front Endocrinol (Lausanne) Date: 2018-01-11 Impact factor: 5.555